The effects of intracisternal injection of 6-hydroxydopamine on three behavioral tasks in the rat were measured 8 to 15 wk. after injection. When animals were sacrificed 21 wk. after injection of 6-hydroxydopamine whole brain norepinephrine levels were reduced to 40% of control values. General activity levels were not altered in rats given 6-hydroxydopamine. However, the behavioral stimulation produced by d-amphetamine was much lower in animals treated with 6-hydroxydopamine than in controls. 6-hydroxydopamine-treated rats also exhibited more foot-shock-induced aggression and showed a trend toward slower active avoidance acquisition.
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