A model of the brain is presented at both molecular and molar levels. Communication between neurons is thought to be a kind of telegraph code, with the information being coded as the permutation of four possible interval values between successive action potentials in spike trains. A small species of RNA molecule is thought to be the memory molecule, and the four possible nucleotide bases of RNA correspond to the four possible interval values. The model is shown to account for generalization, speed of retrieval, mass action, long- and short-term memory, forgetting, operant and classical conditioning, intelligence, reaction time, the action of anaesthetic agents, and some aspects of personality. Some evidence from multidisciplinary sources is presented in support of the major features of the model.
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References
1.
BrinkF.Jr.Excitation and conduction in the neuron. In StevensS. S. (Ed.), Handbook of experimental psychology. New York: Wiley, 1951. Pp. 50–93.
2.
CoxR. A.PeacockeA. R.Application of the titration method to studies on the denaturation of sodium deoxyribonucleate. J. Polymer Science, 1957, 23, 765–779.
3.
DavidsonJ. N.The biochemistry of the nucleic acids. London: Methuen, 1969.
4.
DoeminN. N.Effects of acetylcholine and adrenaline upon some sites of nucleic acid metabolism in single cells and subcellular fractions of nervous tissue. In LodinZ.RoseS. P. R. (Eds.), Macromolecules and the function of the neurone. Amsterdam: Excerpta Medica Found., 1968. Pp. 316–323.
5.
EdstromA.Identification and properties of RNA from Mauthner nerve fiber components of the goldfish. In LodinZ.RoseS. P. R. (Eds.), Macromolecules and the function of the neurone. Amsterdam: Excerpta Medica Found., 1968. Pp. 103–110.
6.
EgyhaziE.HydenH.Experimentally induced changes in the base composition of the ribonucleic acids of isolated nerve cells and their oligodendroglial cells. J. Biophys. Biochem. Cytol., 1961, 10, 403–410.
7.
EmersonC. P. E.BragdowJ. S.Essentials of medicine. London: Pitman Med., 1955.
8.
EmpsonJ. A. C.ClarkeP. R. F.Rapid eye movements and remembering. Nature, 1970, 227, 287–288.
9.
EysenckH. J.The biological basis of personality. Springfield: Thomas, 1967.
10.
GaitoJ.Macromolecules and learning. In BourneG. H. (Ed.), The structure and function of nervous tissue. London: Academic Press, 1969. Pp. 493–516.
11.
GeldardF. A.The human senses. New York: Wiley, 1953.
12.
HydenH.RNA in brain cells. In QuartonG. C.. (Eds.), Neurosciences. New York: Rockefeller Univer. Press, 1967. Pp. 248–266.
13.
HydenH.Biochemical approaches to learning and memory. In KoestlerA.SmythiesJ. R. (Eds.), Beyond reductionism. London: Hutchinson, 1969. Pp. 85–103.
14.
KiangN. Y.Discharge patterns of single fibers in the cat's auditory nerve. Cambridge: M. I. T. Press, 1965.
15.
LaserR. J.The distribution of nucleic acids in the giant axon of the squid (Loligo pealii). J. Neurochem., 1970, 17, 103–109.
16.
LashleyK. S.In search of the engram. In BeachF. A. (Eds.), The neuropsychology of Lashley: Selected papers of K. S. Lashley. London: McGraw-Hill, 1960. Pp. 478–486.
17.
MillerG. A.The magical number seven, plus or minus two: Some limits on cur capacity for processing information. Psychol. Rev., 1956, 63, 81–97.
18.
MorganC. T.StellarE.Physiological psychology. New York: McGraw-Hill, 1950.
19.
NovikoffA. B.Enzyme localization and ultrastructure of neurons. In HydenH. (Ed.), The neuron. Amsterdam: Elsevier, 1967. Pp. 255–318.
20.
NymanM.WhittakerV. P.The distribution of adenosine triphosphate in subcellular fractions of brain tissue. Biochem. J., 1963, 87, 248–255.
21.
PimentalG. C.McClellanA. L.The hydrogen bond. London: W. H. Freeman, 1960.
22.
PomeratC. M.Dynamic activities of nervous tissue. In HydenH. (Ed.), The neuron. Amsterdam: Elsevier, 1967. Pp. 119–178.
23.
RosenblattR.FarrowJ. T.RhineS.The transfer of learned behaviour from trained to untrained rats by means of brain extracts: II. Proc. Nat. Acad. of Sci., 1966, 55, 787–792.
24.
TaxiJ.Observations on the ultra structure of the gangtronic neurons and synapses of the frog (Rana escutental). In HydenH. (Ed.), The neuron. Amsterdam: Elsevier, 1967. Pp. 221–254.
25.
WerreP. F.The relationship between EEG and psychological data in normal adults. Leiden: Universitaire Pers Leiden, 1957.
