6-FDET has been shown to produce the autonomic symptoms and mood changes characteristic of hallucinogens, but not perceptual and thinking disturbances. Hence it has been tested as an active placebo in clinical studies. In the absence of behavioral information about this drug, several studies were run to assess its effect on certain rat behaviors. It was found that 6-FDET exerts a fast-acting, relatively short-lived inhibitory effect on drinking and water-motivated behaviors. No evidence was found to indicate that 6-FDET affects acquisition of conditioned suppression.
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