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Abstract

This study is an attempt to dimensionalize the affective responses of normal humans to some common psychoactive drugs. To this end, the methods of factor analysis were applied to a drug X mood correlation matrix. This technique differs radically from previous applications of factor analysis to mood effects, in that the latter characteristically analyze a mood X subject matrix. Thus, instead of reflecting the organization of individual differences, the resulting factor structure represented a mood-dimension space in which drug effects were resolved as vectors. Amphetamines were found to produce strong effects along three mood dimensions, whose relative strengths depend upon dosage, latency, and a strong dosage X latency interaction. Susceptibility to independent manipulation by dosage-latency variations implies that the three dimensions constitute more than statistical abstractions and may represent isolable biochemical events.

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Some Dimensions of Affective Response to Drugs

Abstract

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References