Cortical and Subcortical Dynamics of Aging with HIV Infection

Abstract

Given pharmaceutical advancements, more people with HIV will be living to old age. Cognitive declines have been observed both during normal aging and in people with HIV; whether there are cumulative cognitive declines in adults aging with HIV remains unknown. Based on current literature, adults aging with HIV may be at risk for psychomotor declines that resemble parkinsonianism.

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References

Aylward

E. H.

Henderer

J. D.

McArthur

J. C.

Brettschneider

P. D.

Harris

G. J.

Barta

P. E.

, & Pearlson

G. D.

(1993) Reduced basal ganglia volume in HIV-1 associated dementia: Results from quantitative neuroimaging. Neurology, 43, 2099–2104.

Bachus

M. A.

(1998) HIV and the older adult. Journal of Gerontological Nursing, 24, 41–46.

Belzie

L. R.

(1996) Risperidone for AIDS-associated dementia: A case series. AIDS Patient Care & STDs, 10, 246–249.

Ben-Shlomo

(1997) The epidemiology of Parkinson's disease. Baillieres Clinical Neurology, 6, 55–68.

Bornstein

R. A.

Pace

Rosenberger

Nasrallah

H. A.

Para

M. F.

Whitacre

C. C.

, & Fass

R. J.

(1993) Depression and neuropsychological performance in asymptomatic HIV infection. American Journal of Psychiatry, 150, 922–927.

Brink

J. M.

, & McDowd

J. M.

(1999) Aging and selective attention: An issue of complexity or multiple mechanism? Journals of Gerontology, 54, P30–33.

Caparros-Lefebvre

Pecheux

Petit

Duhamel

, & Petit

(1995) Which factors predict cognitive decline in Parkinson's disease? Journal of Neurology, Neurosurgery, and Psychiatry, 58, 51–55.

Centers for Disease Control and Prevention. (1998) AIDS among persons aged >50 years—United States, 1991–1996. Morbidity and Mortality Weekly Report, 47, 21–27.

Christensson

Ljungberg

Ryding

Svenson

, & Rosen

(1999) SPECT with 99mTc-HMPAO in subjects with HIV infections: Cognitive dysfunction correlates with high uptake. Scandinavian Journal of Infectious Disease, 31, 349–354.

10.

Corless

I. B.

Bakken

Nicholas

P. K.

Holzemer

W. L.

McGibbon

C. A.

Inouye

Nokes

K. M.

Turner

J. G.

Powell-Cope

G. M.

Brown

M. A.

, & Portillo

C. J.

(2000) Predictors of perception of cognitive functioning in HIV/AIDS. Journal of the Association of Nurses in AIDS Care, 11(3), 19–26.

11.

de Rijk

M. C.

Tzourio

Breteler

M. M. B.

Dartigues

J. F.

Amaducci

Lopez-Pousa

Manubens-Bertran

J. M.

Alperovitch

, & Rocca

W. A.

(1997) Prevalence of parkinsonianism and Parkinson's disease in Europe: The Europarkinson Collaborative Study. Journal of Neurology, Neurosurgery, and Psychiatry, 62, 10–15.

12.

Edwards

J. D.

Wadley

V. G.

Myers

R. S.

Roenker

D. L.

Cissell

G. M.

, & Ball

K. K.

(2002) Transfer of a speed of processing intervention to near and far cognitive functions. Gerontology, 47, 1–22.

13.

Everall

I. P.

Luthert

P. J.

, & Lantos

P. L.

(1991) Neuronal loss in the frontal cortex in HIV infection. Lancet, 337, 1119–1121.

14.

Flaherty

J. H.

(1998) Commonly prescribed and over-the-counter remedies: Causes of confusion. Clinics in Geriatric Medicine, 14, 101–127.

15.

Floyd

, & Scogin

(1997) Effects of memory training on the subjective memory functioning and mental health of older adults: A meta-analysis. Psychology and Aging, 12, 150–161.

16.

Fry

A. F.

, & Hale

(1996) Processing speed, working memory, and fluid intelligence: Evidence for a developmental cascade. Psychological Science, 1, 237–241.

17.

Grassi

M. P.

Clerici

Perin

Zocchetti

Borella

Cargnel

, & Mangoni

(1995) HIV infection and drug use: Influence on cognitive function. AIDS, 9, 165–170.

18.

Groves

P. M.

, & Rebec

G. V.

(1992) Introduction to biological psychology. Dubuque, IA: Brown.

19.

Harris

G. J.

Pearlson

G. D.

McArthur

J. C.

Zeger

, & LaFrance

N. D.

(1994) Altered cortical blood flow in HIV-seropositive individuals with and without dementia: A single photon emission computed tomography study. AIDS, 8, 495–499.

20.

Heath

K. V.

Hogg

R. S.

Chan

K. J.

Harris

Montessori

O'Shaughnessy

M. V.

, & Montanera

J. S.

(2001) Lipodystrophy-associated morphological, cholesterol and triglyceride abnormalities in a population-based HIV/AIDS treatment database. AIDS, 15, 231–239.

21.

D. D.

Neumann

A. U.

Perelson

A. S.

Chen

Leonard

J. M.

, & Markowitz

(1995) Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature, 373(6510), 123–126.

22.

Julien

R. M.

(1998) A primer of drug action. New York: Freeman.

23.

Kail

, & Salthouse

T. A.

(1994) Processing speed as a mental capacity. Acta Psychologica, 86, 199–225.

24.

Kolson

D. L.

, & Gonzalez-Scarano

(2002) The effects of human immunodeficiency virus in the central nervous system. Advances in Virus Research, 50, 1–47.

25.

Korten

A. E.

Henderson

A. S.

Christensen

Jorm

A. F.

Rodgers

Jacomb

, & MacKinnon

A. J.

(1997) A prospective study of cognitive function in the elderly. Psychological Medicine, 27, 919–930.

26.

Lang

J. P.

Halleguen

Picard

Lang

J. M.

, & Danion

J. M.

(2001) Apropos of atypical melancholia with Sustiva (efavirenz). Encephale, 21, 290–293.

27.

Linjakumpu

Hartikainen

Klaukka

Veijola

Kivela

S. L.

, & Isoaho

(2002) Use of medications and polypharmacy are increasing among the elderly. Journal of Clinical Epidemiology, 55, 809–817.

28.

MacPherson

S. E.

Phillips

L. H.

, & Sala

Della S.

(2002) Age, executive function, and social decision making: A dorsolateral prefrontal theory of cognitive aging. Psychology & Aging, 17, 598–609.

29.

Martin-Garcia

Kolson

D. L.

, & Gonzalez-Scarano

(2002) Chemokine receptors in the brain: Their role in HIV infection and pathogensis. AIDS, 16, 1709–1730.

30.

Masliah

Morey

DeTeresa

Terry

R. D.

, & Wiley

C. A.

(1992) Cortical dendritic pathology in human immunodeficiency virus encephalitis. Laboratory Investigation, 66, 285–291.

31.

Mattay

V. S.

Fera

Tessitore

Hariri

A. R.

Das

Callicott

J. H.

, & Weinberger

D. R.

(2002) Neurophysiological correlates of age-related changes in human motor function. Neurology, 58, 630–635.

32.

McDowd

J. M.

(1997) Inhibition in attention and aging. Journals of Gerontology, 52, 265–273.

33.

Merrill

J. E.

, & Chen

I. S.

(1991) HIV-1, macrophages, glial cells, and cytokines in AIDS nervous system disease. FASEB Journal, 5, 2391–2397.

34.

Miller

E. N.

Selnes

O. A.

McArthur

J. C.

Satz

Becker

J. T.

Cohen

B. A.

Sheridan

Machado

A. M.

Van Gorp

W. B.

, & Visscher

(1990) Neuropsychological performance in HIV-1 infected homosexual men: The Multicenter AIDS Cohort Study (MACS). Neurology, 40, 197–203.

35.

Moore

L. W.

, & Amburgey

L. B.

(2000) Older adults with HIV. AJORN Journal, 71, 873–876.

36.

Morley

(1999) Immunosenescence. In Coe

(Ed.), Geriatric science. Baltimore, MD: Johns Hopkins Univer. Press.

37.

Nath

Anderson

Jones

Maragos

Booze

Mactutus

Bell

Hauser

K. F.

, & Mattson

(2000) Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia. Journal of Psychopharmacology, 14, 222–227.

38.

Osowiecki

D. M.

Cohen

R. A.

Morrow

K. M.

Paul

R. H.

Carpenter

C. C.

Flanigan

, & Boland

R. J.

(2000) Neurocognitive and psychological contributions to quality of life in HIV-1 infected women. AIDS, 14, 1327–1332.

39.

Papella

F. J.

Delaney

K. M.

Moorman

A. C.

Loveless

M. O.

Fuhrer

Satten

G. A.

Aschman

D. J.

, Holmberg, S. D., & the HIV Outpatient Study. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. New England Journal of Medicine, 338, 853–860.

40.

Paulsen

J. S.

Butter

Sadek

J. R.

Johnson

S. A.

Salmon

D. P.

Swerdlow

N. R.

, & Swenson

M. R.

(1995) Distinct cognitive profiles of cortical and subcortical dementia in advanced illness. Neurology, 45, 951–956.

41.

Power

Kong

P. A.

Crawford

T. O.

Wesselingh

Glass

J. D.

McArthur

J. C.

, & Trapp

B. D.

(1993) Cerebral white matter changes in acquired immunodeficiency syndrome dementia: Alteration of the blood-brain barrier. Annals of Neurology, 34, 339–350.

42.

Price

R. W.

Brew

Sidtis

Rosenblum

Scheck

A. D.

, & Cleary

(1988) The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex. Science, 239, 586–596.

43.

Pugh

K. G.

, & Lipsitz

L. A.

(2002) The microvascular frontal-subcortical syndrome of aging. Neurobiology of Aging, 23, 421–431.

44.

Richelson

(1996) Preclinical pharmacology of neuroleptics: Focus on new generation compounds. Journal of Clinical Psychiatry, 57, 4–11.

45.

Sacktor

N. C.

Lyles

R. H.

Skolasky

R. L.

Anderson

D. E.

McArthur

J. C.

McFarlane

Selnes

O. A.

Becker

J. T.

Cohen

Wesch

, & Miller

E. N.

(1999) Combination antiretroviral therapy improves psychomotor speed performance in HIV-seropositive homosexual men. Neurology, 52, 1640–1647.

46.

Schaie

K. W.

(1996) Intellectual development in adults: The Seattle Longitudinal Study. New York: Cambridge.

47.

Schut

L. J.

(1998) Motor system changes in the aging brain: What is normal and what is not. Geriatrics, 53, 16–19.

48.

Stern

(1994) Neuropsychiatric aspects of HIV, with a note on psychoneuroimmunology. Advances: Journal of the Institute for the Advancement of Health, 10, 28–31.

49.

Suarez

Baril

Stankoff

Khellaf

Dubois

Lubetzki

Bricaire

, & Hauw

J. J.

(2001) Outcome of patients with HIV-1-related cognitive impairment on highly active antiretroviral therapy. AIDS, 15, 195–200.

50.

Vance

D. E.

(2002) Aging successfully with HIV. Presented at American Society on Aging Conference, Denver, CO.

51.

Vance

D. E.

(2003) The psychological effects of aging with HIV. Presented at American Society on Aging Conference, Chicago, IL.

52.

West

R. L.

(1996) An application of prefrontal cortex function theory to cognitive aging. Psychological Bulletin, 120, 488–507.

53.

Wiley

C. A.

Masliah

Morey

Lemere

DeTeresa

Grafe

Hansen

, & Terry

(1991) Neocortical damage during HIV infection. Annals of Neurology, 29, 651–657.

54.

Williams

K. C.

, & Hickey

W. F.

(2002) Central nervous system damage, monocytes and macrophages, and neurological disorders in AIDS. Annual Review of Neuroscience, 25, 537–562.

55.

Wilson

R. S.

, & Gilley

D. W.

(1992) Ideational fluency in Parkinson's disease. Brain and Cognition, 20, 236–244.