The Autopsy and Toxicologic Deaths

Abstract

Deaths from toxicologic causes is one of the main reasons for performing an autopsy. The approach to performing an autopsy involves knowledge of the scene and history, particularly for the presence of prescribed and illicit drugs. The external and internal examination, while often nonspecific, can provide specific information on route of administration and specific changes seen on naked eye and microscopic examination. Material for toxicologic analysis needs to be collected and may require discussion with the toxicology laboratory to make sure the appropriate material is sent. The opinion relating to cause and manner of death requires an analysis of all stages of the investigation. Such phenomena as postmortem redistribution and tolerance to a drug must be considered before making a determination. This paper reviews the autopsy in toxicologic death.