Massive placental perivillous fibrinoid deposition in the placenta is thought to be an immune-related condition associated with poor perinatal outcomes, including growth restriction and intrauterine fetal demise, with a high risk of recurrence. Rare cases have been associated with Coxsackievirus infection. We present such a case and review the literature.
WhittenAE, RomeroR, KorzeniewskiSJEvidence of an imbalance of angiogenic/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): a placental lesion associated with recurrent miscarriage and fetal death. Am J Obstet Gynecol2013;208:310.e1–310.e11.
4.
RomeroR, WhittenA, KorzeniewskiSJMaternal floor infarction/massive perivillous fibrin deposition: a manifestation of maternal antifetal rejection. Am J Reprod Immunol2013;70:285–298.
5.
YuW, TellierR, WrightJRJr.Coxsackie virus A16 infection of the placenta with massive perivillous fibrin deposition leading to intrauterine fetal demise at 36 weeks gestation. Pediatr Dev Pathol2015;18:331–334.
6.
BatcupG, HoltP, HamblingMH, GerlisLM, GlassMR.Placental and fetal pathology in Coxsackie virus A9 infection: a case report. Histopathology1985;9:1227–1235.
7.
AmsteyMS, MillerRK, MunegusMA, di Sant'AgnesePA.Enterovirus in pregnant women and the perfused placenta. Am J Obstet Gynecol1988;158:775.
8.
OgilvieMM, TearneDF.Spontaneous abortion after hand-foot-and-mouth disease caused by Coxsackie virus A16. Br Med J1980;281:1527–1528.
9.
MuehlenbachsA, BhatnagarJ, ZakiSR.Tissue tropism, pathology and pathogenesis of enterovirus infection. J Pathol2015;235:217–228.
10.
EuscherE, DavisJ, HolzmanI, NuovoGJ.Coxsackie virus infection of the placenta associated with neurodevelopmental delays in the newborn. Obstet Gynecol2001;98:1019–1026.
11.
ChowK, LeeC, LinTCongenital enterovirus 71 infection: a case study with virology and immunohistochemistry. Clin Infect Dis2000;31:509–512.
12.
GarciaAG, BassoNG, FonsecaME, OutaniHN.Congenital echo virus infection—morphological and virological study of fetal and placental tissue. J Pathol1990;160:123–127.
13.
Delorme-AxfordE, SadovskyY, CoyneCB.Lipid raft- and SRC family kinase-dependent entry of coxsackievirus B into human placental trophoblasts. J Virol2013;87:8569–8581.
14.
KonstantinidouA, AnninosH, SpanakisNTransplacental infection of Coxsackievirus B3 pathological findings in the fetus. J Med Virol2007;79:754–757.
