Our goal was to set up a clinical service for minimally invasive postmortem examination for the fetal and neonatal age group. The minimally invasive service consisted of imaging, external review, placental examination, and ancillary tests that form part of the formal autopsy process. Eleven patients had imaging and relevant conditions at death successfully determined with the minimally invasive service. We conclude that a minimally invasive autopsy service for fetal and neonatal cases is possible and acceptable to patients and professionals.
ThayyilS. Less invasive autopsy: an evidenced based approach. Arch Dis Child2011;96:681–687.
2.
ThayyilSClearyJOSebireNJ. Post-mortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet2009;374:467–475.
3.
CohenMCPaleyMNGriffithsPDWhitbyEH. Less invasive autopsy: benefits and limitations of the use of magnetic resonance imaging in the perinatal postmortem. Pediatr Dev Pathol2008;11:1–9.
4.
GriffithsPDPaleyMNWhitbyEH. Post-mortem MRI as an adjunct to fetal or neonatal autopsy. Lancet2005;365:1271–1273.
WhitbyEHPaleyMNCohenMGriffithsPD. Postmortem MR imaging of the fetus: an adjunct or a replacement for conventional autopsy?Semin Fetal Neonatal Med2005;10:475–483.
7.
BrookesJADengJWilkinsonIDLeesWR. Three-dimensional imaging of the postmortem fetus by MRI: early experience. Fetal Diagn Ther1999;14:166–171.
8.
BrookesJSHagmannC. MRI in fetal necropsy. J Magn Reson Imaging2006;24:1221–1228.
9.
BrookesJSHall-CraggsMA. Postmortem perinatal examination: the role of magnetic resonance imaging. Ultrasound Obstet Gynecol1997;9:145–147.
10.
ThayyilSSebireNJChittyLS; MARIAS Collaborative Group. Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet2013;382:223–233.
11.
WidjajaEWhitbyEHCohenMPaleyMNGriffithsPD. Postmortem MRI of the foetal spine and spinal cord. Clin Radiol2006; 61:679–685.
12.
WidjajaEWhitbyEHPaleyMNGriffithsPD. Normal fetal lumbar spine on postmortem MR imaging. AJNR Am J Neuroradiol2006;27:553–559.
13.
GardosiJKadySMMcGeownPFrancisATonksA. Classification of stillbirth by relevant condition at death (ReCoDe): population based cohort study. BMJ2005;331:1113–1117.
14.
RosaiJ. The posthumous analysis (PHA): an alternative to the conventional autopsy. Am J Clin Pathol1996;106:S15–S17.
15.
NHS Expert Advisory Group, University of Leicester. Can cross-sectional imaging as an adjunct and/or alternative to the invasive autopsy be implemented within the NHS? August 2012. Available at http://www2.le.ac.uk/departments/emfpu/national-documents-1. Accessed October 10, 2013.
