Massive perivillous fibrin deposition (MPVFD) of the placenta and renal tubular dysgenesis (RTD) are relatively rare diseases with potential recurrent risks that have not previously associated in the literature. Herein, we report the clinical course, autopsy findings, and placental pathologic features from 3 consecutive pregnancies delivered in 1 woman, all showing recurrent MPVFD in the placenta and RTD in the bilateral fetal kidneys.
AndresRLKuyperWResnikRPiacquadioKMBenirschkeK. The association of maternal floor infarction of the placenta with adverse perinatal outcome. Am J Obstet Gynecol1990;163:935–938.
BenirschkeKDriscollS. Pathology of the Human Placenta. Maternal Floor Infarction. In: BenirschkeKBurtonGJBaergenRN, eds. New York: Springer-Verlag, 1967;328–330.
4.
KatzmanPJGenestDR. Maternal floor infarction and massive perivillous fibrin deposition: histological definitions, association with intrauterine fetal growth restriction, and risk of recurrence. Pediatr Dev Pathol2002;5:159–164.
5.
RedlineRW. Maternal floor infarction and massive perivillous fibrin deposition: clinicopathologic entities in flux. Adv Anat Pathol2002;9:372–373.
6.
BenirschkeK. Pathology of the Human Placenta. New York: Springer, 2012.
7.
RedlineRWJiangJGShahD. Discordancy for maternal floor infarction in dizygotic twin placentas. Hum Pathol2003;34:822–824.
8.
FukeYAonoTImaiSSueharaNFujitaTNakayamaM. Clinical significance and treatment of massive intervillous fibrin deposition associated with recurrent fetal growth retardation. Gynecol Obstet Invest1994;38:5–9.
BendonRWHommelAB. Maternal floor infarction in autoimmune disease: two cases. Pediatr Pathol Lab Med1996;16:293–297.
11.
ChangPMillarMTsangPLimKHoulihanEStephensonM. Intravenous immunoglobulin in antiphospholipid syndrome and maternal floor infarction when standard treatment fails: a case report. Am J Perinatol2006;23:125–129.
12.
HungNAJacksonCNicholsonMHightonJ. Pregnancy-related polymyositis and massive perivillous fibrin deposition in the placenta: are they pathogenetically related?Arthritis Rheum2006; 55:154–156.
13.
SebireNJBackosMEl GaddalSGoldinRDReganL. Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients. Obstet Gynecol2003;101:258–263.
GogiaNMachinGA. Maternal thrombophilias are associated with specific placental lesions. Pediatr Dev Pathol2008;11:424–429.
16.
KatzVLDtTomassoJFarmerRCarpenterM. Activated protein C resistance associated with maternal floor infarction treated with low-molecular-weightheparin. Am J Perinatol2002;19:273–277.
17.
SvenssonAMWatersBLaszikZG, The protein C system in placental massive perivillous fibrin deposition. Blood Coagul Fibrinolysis2004;15:491–495.
18.
MaternDSchehataBMShekhawaPStraussAWBennettMJRinaldoP. Placental floor infarction complicating the pregnancy of a fetus with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. Mol Genet Metab2001;72:265–268.
19.
GriffinACStraussAWBennettMJErnstLM. Mutations in long-chain 3-hydroxyacyl coenzyme a dehydrogenase are associated with placental maternal floor infarction/massive perivillous fibrin deposition. Pediatr Dev Pathol2012;15:368–374.
20.
WhittenAERomeroRKorzeniewskiSJ. Evidence of an imbalance of angiogenic/antiangiogenic factors in massive perivillous fibrin deposition (maternal floor infarction): a placental lesion associated with recurrent miscarriage and fetal death. Am J Obstet Gynecol2013;208:310.e1–310.e11.
21.
TaweevisitMThornerPS. Maternal floor infarction associated with oligohydramnios and cystic renal dysplasia: report of 2 cases. Pediatr Dev Pathol2010;13:116–120.
22.
HansenKSungCJHuangCPinarHSingerDBOyerCE. Reference values for second trimester fetal and neonatal organ weights and measurements. Pediatr Dev Pathol2003;6:160–167.
23.
FoxHElstonCW. Pathology of the Placenta. Major Problems in Pathology. Philadelphia: Saunders, 1978.
24.
BenirschkeKDriscollSG. The Pathology of the Human Placenta. Berlin, New York: Springer-Verlag; 1967.
25.
KaufmannPHuppertzBFrankHG. The fibrinoids of the human placenta: origin, composition and functional relevance. Ann Anat1996;178:485–501.
26.
BaergenRN. Manual of Pathology of the Human Placenta, 2nd ed.New York: Springer, 2011.
27.
VernofKKBenirschkeKKephartGMWasmoenTLGleichGJ. Maternal floor infarction: relationship to X cells, major basic protein, and adverse perinatal outcome. Am J Obstet Gynecol1992;167:1355–1363.
28.
MandsagerNTBendonRMostelloDRosennBMiodovnikMSiddiqiTA. Maternal floor infarction of the placenta: prenatal diagnosis and clinical significance. Obstet Gynecol1994;83:750–754.
29.
Adams-ChapmanIVaucherYEBejarRFBenirschkeKBaergenRNMooreTR. Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome. J Perinatol2002;22:236–241.
30.
ClewellWHManchesterDK. Recurrent maternal floor infarction: a preventable cause of fetal death. Am J Obstet Gynecol1983;147:346–347.
31.
NickelRE. Maternal floor infarction: an unusual cause of intrauterine growth retardation. Am J Dis Child1988;142:1270–1271.
32.
WatersBLAshikagaT. Significance of perivillous fibrin/oid deposition in uterine evacuation specimens. Am J Surg Pathol2006; 30:760–765.
33.
GenestDRLageJM. Absence of normal-appearing proximal tubules in the fetal and neonatal kidney: prevalence and significance. Hum Pathol1991;22:147–153.
34.
AllansonJEPantzarJTMacLeodPM. Possible new autosomal recessive syndrome with unusual renal histopathological changes. Am J Med Genet1983;16:57–60.
35.
MacMahonPBlackieRASHouseMJRisdonRAd'A CrawfurdM. A further family with congenital renal proximal tubular dysgenesis. J Med Genet1990;27:395–398.
36.
AllansonJEHunterAGMettlerGSJimenezC. Renal tubular dysgenesis: a not uncommon autosomal recessive syndrome: a review. Am J Med Genet1992;43:811–814.
37.
SchwartzBRLageJMPoberBRDriscollSG. Isolated congenital renal tubular immaturity in siblings. Hum Pathol1986;17:1259–1263.
38.
LacosteMCaiYGuicharnaudL. Renal tubular dysgenesis, a not uncommon autosomal recessive disorder leading to oligohydramnios: role of the renin-angiotensin system. J Am Soc Nephrol2006;17:2253–2263.
39.
VolandJRHawkinsEPWellsTRSaundersBJonesMBenirschkeK. Congenital hypernephronic nephromegaly with tubular dysgenesis: a distinctive inherited renal anomaly. Pediatr Pathol1985;4:231–245.
40.
GribouvalOMoriniereVPawtowskiA. Spectrum of mutations in the renin-angiotensin system genes in autosomal recessive renal tubular dysgenesis. Hum Mutat2012;33:316–326.
41.
GublerMCAntignacC. Renin-angiotensin system in kidney development: renal tubular dysgenesis. Kidney Int2010;77:400–406.
42.
ObergKCMoriniereVPawtowskiA. Renal tubular dysgenesis in twin-twin transfusion syndrome. Pediatr Dev Pathol1999;2:25–32.