A mesenchymal hamartoma of the liver (MHL) from a 20-month-old girl was studied cytogenetically. The karyotype was 46,XX,inv(19)(p13q13.4)[38], and fluorescence in situ hybridization using bacterial artificial chromosome probes refined the breakpoints to 19p13.11 and the subtelomeric region of 19q. This is the first report of inversion (19) in MHL, and the q-arm breakpoint is different from that reported previously in other rearrangements.
BoveKEBloughRISoukupS. Third report of t(19q)(13.4) in mesenchymal hamartoma of liver with comments on link to embryonal sarcoma. Pediatr Dev Pathol1998;1:438–442.
2.
MascarelloJTKrousHF. Second report of a translocation involving 19q13.4 in a mesenchymal hamartoma of the liver. Cancer Genet Cytogenet1992;58:141–142.
3.
RakhejaDMargrafLRTomlinsonGESchneiderNR. Hepatic mesenchymal hamartoma with translocation involving chromosome band 19q13.4: a recurrent abnormality. Cancer Genet Cytogenet2004;153:60–63.
4.
SharifKRamaniPLochbühlerHGrundyRde Ville de GoyetJ. Recurrent mesenchymal hamartoma associated with 19q translocation. A call for more radical surgical resection. Eur J Pediatr Surg2006;16:64–67.
5.
SpelemanFDe TelderVDe PotterKR. Cytogenetic analysis of a mesenchymal hamartoma of the liver. Cancer Genet Cytogenet1989;40:29–32.
6.
MurthiGVSPatersonLAzmyA. Chromosomal translocation in mesenchymal hamartoma of liver: what is its significance?J Pediatr Surg2003;38:1543–1545.
7.
TalmonGACohenSM. Mesenchymal hamartoma of the liver with an interstitial deletion involving chromosome band 19q13.4. Arch Pathol Lab Med2006;130:1216–1218.
8.
BaboiuO-ESaalHCollinsM. Hepatic mesenchymal hamartoma: cytogenetic analysis of a case and review of the literature. Pediatr Dev Pathol2008;11:295–299.
9.
O'SullivanMJSwansonPEKnollJTaboadaEMDehnerLP. Undifferentiated embryonal sarcoma with unusual features arising within mesenchymal hamartoma of the liver: report of a case and review of the literature. Pediatr Dev Pathol2001;4:482–489.
10.
RajaramVKnezevichSBoveKEPerryAPfeiferJD. DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chromosomes Cancer2007;46:508–513.
11.
LauwersGYGrantLDDonnellyWH. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol1997;21:1248–1254.
12.
MudduluruGVajkoczyPAllgayerH. Myeloid zinc finger 1 induces migration, invasion, and in vivo metastasis through Axl gene expression in solid cancer. Mol Cancer Res2010;8: 159–169.
13.
JiangXYuYYangHWAgarNYFradoLJohnsonMD. The imprinted gene PEG3 inhibits Wnt signalling and regulates glioma growth. J Biol Chem2010;285:8472–8480.
14.
IshikawaSKobayashiIHamadaJ. Interaction of MCC2,a novel homologue of MCC tumor suppressor, with PDZ-domain protein AIE-75. Gene2001;267:101–110.
15.
ReedRCKapurRP. Hepatic mesenchymal hamartoma: a disorder of imprinting?Pediatr Dev Pathol2008;11:264–265.
16.
GheldofNSmithEMTabuchiTM. Cell-type-specific long-range looping interactions identify distant regulatory elements of the CFTR gene. Nucleic Acids Res2010;38:4325–4336.
17.
AshworthKJBranscombLEStubbsL. The human homolog of a mouse imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4.1. Genome Res1997;7:532–540.
18.
StringerMDAlizaiNK. Mesenchymal hamartoma of the liver: a systematic review. J Pediatr Surg2005;40:1681–1690.
