Spindle cell lesions within lymph nodes generally raise concern for metastasis. We report the 1st intranodal hybrid schwannoma/perineurioma arising in an inguinal lymph node in a 13-year-old boy. Presentation comprised a painless, slowly enlarging mass in a patient with no clinical features of neurofibromatosis.
GriffithsAPIronsideJWGrayC. True neurilemmoma arising in a lymph node in infancy. Histopathology1991;18:180–183.
2.
PianaSGelliMCCavazzaA. Ancient schwannoma arising in a lymph node. Report of a case and review of the literature. Pathol Res Pract2002;198:51–54.
3.
ReinusCShutinOReissmanP. Intranodal schwannoma presenting as an adrenal mass. Histopathology2004;45:95–96.
4.
BlackJOZhaiQJVaronaOB. Primary schwannoma in a cervical lymph node. Head Neck2010;32:964–969.
5.
GrantDGBreitenfeldtNShepherdNA. Intranodal neurilemmoma presenting as parotid mass. J Laryngol Otol2009;123:912–914.
6.
JungJHYooJKangSJ. Schwannoma arising in a lymph node. A brief case report. Korean J Pathol2009;43:271–273.
7.
FeanyMBAnthonyDCFletcherCDM. Nerve sheath tumours with hybrid features of neurofibroma and schwannoma: a conceptual challenge. Histopathology1998;32:405–410.
8.
MichalMKazakovDVBelousovaI. A benign neoplasm with histopathological features of both schwannoma and retiform perineurioma (benign schwannoma-perineurioma): a report of six cases of a distinctive soft tissue tumor with a predilection for the fingers. Virchows Arch2004;445:347–353.
9.
EmanuelPPertsemlidisDSGordonR. Benign hybrid perineurioma-schwannoma in the colon. A case report. Ann Diagn Pathol2006;10:367–370.
10.
ShelekhovaKVDanilovaABMichalM. Hybrid neurofibromaperineurioma: an additional example of an extradigital tumour. Ann Diagn Pathol2008;12:233–234.
11.
HornickJLBundockEAFletcherCDM. Hybrid schwannoma/perineurioma. Clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol2009;33:1554–1561.
12.
Stemmer-RachamimovAOWiestlerODLouisDN. Neurofibromatosis Type 2. In: LouisDNOhgakiHWiestlerODCaveneeWK, eds. WHO Classification of Tumours of the Central Nervous System. Lyon, France: IARC, 2007;219–222.
13.
NascimentoAFFletcherCDM. The controversial nosology of benign nerve sheath tumors: neurofilament staining demonstrates intratumoral axons in many sporadic schwannomas. Am J Surg Pathol2007;31:1363–1370.