Although the occurrence of psoriasis and vitiligo is reported in a few studies, no proper relationship has been found between these two diseases.
Objective
The aim of this study was to identify the frequency of the coincidence of these two diseases.
Method
A descriptive and cross-sectional study was conducted on 6,200 patients referred to dermatology clinics from September 2004 to June 2005.
Results
Among these patients, 219 and 154 patients suffered from psoriasis (3.53%) and vitiligo (2.48%), respectively, and 12 patients (0.19%) had psoriasis and vitiligo simultaneously. The coincidence in the psoriasis group was 5.48% and in the vitiligo group was 7.79%, so the coincidence of both diseases was greater than the incidence of each alone. This association was significant (p = .004).
Conclusion
Coincidence of these two diseases was seen, but more studies should be done to find common genetic and immunologic factors.
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References
1.
GriffithsCEM, BarkerJNWN.Psoriasis. In: BurnsT, BreathnachS, CoxN, editors. Rook's textbook of dermatology.8th ed.Oxford (UK): Wiley-Blackwell;2010. p. 20.1–60.
2.
HalderRM, TaliaferroSJ.Vitiligo. In: WolffK, GoldsmithLA, KatzSI, editors. Fitzpatrick's dermatology in general medicine.7th ed.New York: McGraw-Hill;2008. p. 616–22.
3.
AlkhateebA, FainPR, ThodyA.Epidemiology of vitiligo and associated autoimmune diseases in Caucasian probands and their families.Pigment Cell Res2003; 16: 208–14, doi:10.1034/j.1600-0749.2003.00032.x.
4.
NaughtonGK, EisingerM, BystrynJC.Antibodies to normal human melanocytes in vitiligo.J Exp Med1983; 158: 246–51, doi:10.1084/jem.158.1.246.
5.
PalermoB, CampanelliR, GarbelliS.Specific cytotoxic T lymphocyte responses against Melan-A/MART1, tyrosinase and gp100 in vitiligo by the use of major histocompatibility complex/peptide tetramers: the role of cellular immunity in the etiopathogenesis of vitiligo.J Invest Dermatol2001; 117: 326–32, doi:10.1046/j.1523-1747.2001.01408.x.
6.
WuJJ, NguyenTU, PoonKT.The association of psoriasis with autoimmune diseases.J Am Acad Dermatol2012; 67: 924–30, doi:10.1016/j.jaad.2012.04.039.
7.
TsaiT-F, WangT-S, HangS-T.Epidemiology and comorbidities of psoriasis patients in the national database in Taiwan.J Dermatol Sci2011; 63: 40–6, doi:10.1016/j.jdermsci.2011.03.002.
8.
PrinzJC.The role of T cells in psoriasis.J Eur Acad Dermatol Venereol2003; 17: 257–70, doi:10.1046/j.1468-3083.2003.00720.x.
SchlaakJF, BuslauM, JochumW.T cells involved in psoriasis vulgaris belong to the Th1 subset.J Invest Dermatol1994; 102: 145–9, doi:10.1111/1523-1747.ep12371752.
11.
Bata-CsorgoZ, HammerbergC, VoorheesJJ, CooperKD.Intralesional T-lymphocyte activation as a mediator of psoriatic epidermal hyperplasia.J Invest Dermatol1995; 105 (1 Suppl): 89S–94S.
12.
RezaeiN, GavalasNG, WeetmanAP, KempEH.Autoimmunity as an aetiological factor in vitiligo.J Eur Acad Dermatol Venereol2007; 21: 865–76, doi:10.1111/j.1468-3083.2007.02228.x.
13.
Fernandez-ObregonA.Efalizumab and the treatment of a patient presenting with vitiligo and psoriasis.J Am Acad Dermatol2007; 56: AB192.
14.
GudjonsoonJE, ElderJT.Psoriasis. In: WolffK, GoldsmithLA, KatzSI, editors. Fitzpatrick's dermatology in general medicine.7th ed.New York: McGraw-Hill;2008. p. 169–93.
15.
LazarovaR, HristakievaE, LazarovN, ShaniJ.Vitiligo-related neuropeptides in nerve fibers of the skin.Arch Physiol Biochem2000; 108: 262–7, doi:10.1076/1381-3455(200007)108:3;1-Z;FT262.
16.
SaracenoR, KleynCE, TerenghiG, GriffithsCE.The role of neuropeptides in psoriasis.Br J Dermatol2006; 155: 876–82, doi:10.1111/j.1365-2133.2006.07518.x.
17.
CastroCCS.Prevalence of psoriasis in a study of 261 patients with vitiligo.An Bras Dermatol2005; 80: 489–92.
18.
el-MoftyAM, el-MoftyM.Vitiligo. A symptom complex.Int J Dermatol1980; 19: 237–44, doi:10.1111/j.1365-4362.1980.tb00316.x.
19.
LabergeG, MaillouxCM, GowanK.Early disease onset and increased risk of other autoimmune diseases in familial generalized vitiligo.Pigment Cell Res2005; 18: 300–5, doi:10.1111/j.1600-0749.2005.00242.x.
20.
ZhangZ, XuSX, ZhangFY.The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients.Arch Dermatol Res2009; 301: 167–73, doi:10.1007/s00403-008-0900-z.
21.
SandhuK, KaurI, KumarB.Psoriasis and vitiligo.J Am Acad Dermatol2004; 51: 149–50, doi:10.1016/j.jaad.2003.12.014.
