The rapid appearance of multiple new melanocytic nevi is known as eruptive nevi and has been well documented to occur with certain medications, in particular chemotherapeutic agents.
Methods:
We report a case of a woman with melanoma complicated by nodal metastasis who developed multiple melanocytic nevi while on high-dose interferon.
Results:
Serial photographs confirmed that the pigmented lesions were of new onset, whereas histology documented that the lesions were dysplastic nevi. A survey of the literature documented numerous causes of eruptive nevi, which we review. To date, interferon has not been linked to eruptive nevi.
Conclusions:
The phenomenon of eruptive nevi has been attributed to medications, bullous dermatoses, immunosuppression, and systemic conditions and is possibly a paraneoplastic disorder. Interferon appears to be another possible cause of this disorder.
Get full access to this article
View all access options for this article.
References
1.
McCourtCFeigheryCMcIntyreG. Eruptive nevi in prostate cancer: Is this a paraneoplastic phenomenon?Int J Dermatol2013;52:212–3, doi:10.1111/j.1365-4632.2011.05253.x.
2.
KirkwoodJMStrawdermanMHErnstoffMS. Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol1996;14:7–17.
3.
WhiteRMZonLI. Melanocytes in development, regeneration, and cancer. Cell Stem Cell2008;3:242–52, doi:10.1016/j.stem.2008.08.005.
4.
LattoufCSchachnerL. Epidermolysis bullosa simplex, Dowling-Meara type with eruptive nevi. Int J Dermatol2012;51:1094–6, doi:10.1111/j.1365-4632.2011.05102.x.
5.
ArnoldSJBowlingJ. Eruptive acral naevi following chemotherapy for acute lymphoblastic leukaemia follow typical acral dermoscopic patterns. Australas J Dermatol2013;54:126–8, doi:10.1111/j.1440-0960.2012.00937.x.
WondersJDe BoerNKVan WeyenbergSJ. Spot diagnosis: Eruptive melanocytic naevi during azathioprine therapy in Crohn's disease. J Crohns Colitis2012;6:636, doi:10.1016/j.crohns.2012.02.008.
8.
DertliogluSBBitirenMCicekD. A case with postchemotherapy eruptive compound nevus. Indian J Dermatol2011;56:737–9, doi:10.4103/0019-5154.91842.
9.
GkalpakiotisSArenbergerPArenbergerovaM. Eruptive multiple Spitz nevi in a patient with epilepsy and drug addiction. J Dtsch Dermatol Ges2012;10:267–9.
10.
MichelJL. Eruptive naevi associated with octreotide treatment. Ann Dermatol Venereol2011;138:677–80, doi:10.1016/j.annder.2011.05.010.
11.
Ferrándiz-PulidoCFernández-FiguerasMTQuerAFerrándizC. An eruptive pigmented lesion after melanotan injection. Clin Exp Dermatol2011;36:801–2, doi:10.1111/j.1365-2230.2011.04045.x.
12.
ErfanNCardot-LecciaNSirventA. Eruptive nevi following bone marrow transplantation: A reflectance confocal microscopy study. J Eur Acad Dermatol Venereol2012;26:1043–4, doi:10.1111/j.1468-3083.2011.04217.x.
13.
SantiagoFGonçaloMReisJPFigueiredoA. Adverse cutaneous reactions to epidermal growth factor receptor inhibitors: A study of 14 patients. An Bras Dermatol2011;86:483–90, doi:10.1590/S0365-05962011000300010.
14.
JohnJKSmalleyKS. Identification of BRAF mutations in eruptive melanocytic nevi: New insights into melanomagenesis?Expert Rev Anticancer Ther2011;11:711–4, doi:10.1586/era.11.30.
15.
de BoerNKKuyvenhovenJP. Eruptive benign melanocytic naevi during immunosuppressive therapy in a Crohn's disease patient. Inflamm Bowel Dis2011;17:E26, doi:10.1002/ibd.21618.
LópezVMolinaIMartínJM. Eruptive nevi in a patient receiving cyclosporine A for psoriasis treatment. Arch Dermatol2010;146:802–4, doi:10.1001/archdermatol.2010.145.
GelferARiversJK. Long-term follow-up of a patient with eruptive melanocytic nevi after Stevens-Johnson syndrome. Arch Dermatol2007;143:1555–7, doi:10.1001/archderm.143.12.1555.
24.
ReutterJCLongEMMorrellDS. Eruptive postchemotherapy in situ melanomas and dysplastic nevi. Pediatr Dermatol2007;24:135–7, doi:10.1111/j.1525-1470.2007.00359.x.
25.
BovenschenHJTjioeMVermaatH. Induction of eruptive benign melanocytic naevi by immune suppressive agents, including biologicals. Br J Dermatol2006;154:880–4, doi:10.1111/j.1365-2133.2006.07189.x.
26.
Belloni FortinaAPiasericoSZattraEAlaibacM. Dermoscopic features of eruptive melanocytic naevi in an adult patient receiving immunosuppressive therapy for Crohn's disease. Melanoma Res2005;15:223–4, doi:10.1097/00008390-200506000-00014.
27.
AlaibacMPiasericoSRossiCR. Eruptive melanocytic nevi in patients with renal allografts: Report of 10 cases with dermoscopic findings. J Am Acad Dermatol2003;49:1020–2, doi:10.1016/S0190-9622(03)02482-4.
28.
FiroozAKomeiliADowlatiY. Eruptive melanocytic nevi and cherry angiomas secondary to exposure to sulfur mustard gas. J Am Acad Dermatol1999;40:646–7, doi:10.1016/S0190-9622(99)70460-3.
29.
KarrerSSzeimiesRMStolzWLandthalerM. Eruptive melanocytic nevi after chemotherapy. Klin Padiatr1998;210:43–6, doi:10.1055/s-2008-1043847.
30.
ShojiTCockerellCJKoffABBhawanJ. Eruptive melanocytic nevi after Stevens-Johnson syndrome. J Am Acad Dermatol1997;37 (2 Pt 2):337–9, doi:10.1016/S0190-9622(97)80386-6.
31.
RichertSBloomEJFlynnKSeralyMP. Widespread eruptive dermal and atypical melanocytic nevi in association with chronic myelocytic leukemia: Case report and review of the literature. J Am Acad Dermatol1996;35 (2 Pt 2):326–9, doi:10.1016/S0190-9622(96)90661-1.
32.
BetllochIAmadorCChinerE. Eruptive melanocytic nevi in human immunodeficiency virus infection. Int J Dermatol1991;30:303, doi:10.1111/j.1365-4362.1991.tb04645.x.
33.
IbsenHHClemmensenO. Eruptive nevi in Addison's disease. Arch Dermatol1990;126:1239–40, doi:10.1001/archderm.126.9.1239.
34.
DuvicMLoweLRapiniRP. Eruptive dysplastic nevi associated with human immunodeficiency virus infection. Arch Dermatol1989;125:397–401, doi:10.1001/archderm.1989.01670150087015.
35.
EadyRAGilkesJJJonesEW. Eruptive naevi: Report of two cases, with enzyme histochemical, light and electron microscopical findings. Br J Dermatol1977;97:267–78, doi:10.1111/j.1365-2133.1977.tb15182.x.
36.
KopfAWGrupperCBaerRLMitchellJC. Eruptive nevocytic nevi after severe bullous disease. Arch Dermatol1977;113:1080–4, doi:10.1001/archderm.1977.01640080082014.
