Rhabdomyosarcomas are a heterogeneous group of malignant tumors representing the most common soft tissue sarcoma of childhood. A delay in diagnosis is not uncommon.
Objective:
To report a boy with paranasal rhabdomyosarcoma who was misdiagnosed and treated for infantile hemangioma.
Methods and Results:
A 2-year-old Saudi boy who presented with a progressively increasing nasal mass for 18 months was misdiagnosed and treated for infantile hemangioma at an outside hospital. Histopathologic examination revealed paranasal rhabdomyosarcoma.
Conclusion:
We review some clinical clues that can alert the physician to malignant childhood tumors. We also review management options for childhood rhabdomyosarcoma.
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References
1.
WeberCO. Anatomische Untersuchung einer Hypertrophieschen Zunge Nebst Bemekugen uber die Nubildung querquestreifter Muskelfsern. Virchow Arch Pathol Anat1954;7:115.
2.
MerlinoGHelmanLJ. Rhabdomyosarcoma—working out the pathways. Oncogene1999;18:5340–8.
3.
YoungJLMillerRW. Incidence of malignant tumors in US children. J Pediatr1975;86:254–8.
4.
DagherRHelmanL. Rhabdomyosarcoma: An overview. Oncologist1999;4:34–44.
5.
RaneyRBAndersonJRBarrFG. Rhabdomyosarcoma and undifferentiated sarcoma in the first two decades of life: A selective review of Intergroup Rhabdomyosarcoma Study Group experience and rationale for Intergroup Rhabdomyosarcoma Study V. J Pediatr Hematol Oncol2001;23:215–20.
6.
StobbeGDDargeonHW. Embryonal rhabdomyosarcoma of the head and neck in children and adolescents. Cancer1950;3:826–36.
7.
RomualdiCDe PtittàCTombolanL. Defining the gene expression signature of rhabdomyosarcoma by meta-analysis. BMS Genomics2006;7:287.
8.
OdaD. Case challenge. Pathological condition of a newborn child. J Contemp Dent Pract1999;1:50–4.
9.
RagabAHHeynRTefftM. Infants younger than 1 year of age with rhabdomyosarcoma. Cancer1986;58:2606–10.
10.
EjazAWenigBM. Sinonasal undifferentiated carcinoma clinical and pathologic features and a discussion on classification, cellular differentiation, and differential diagnosis. Adv Anat Pathol2005; 12:134–43.
11.
AndersonJGordonAPritchard-JonesKShipleyJ. Genes, chromosomes, and rhabdomyosarcoma. Genes Chromosomes Cancer1999;26:275–85.
12.
FolpeALHillCEParhamDM. Immunohistochemical detection of FLI-1 protein expression. A study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroecdotermal tumor. Am J Surg Pathol2000;24:1657–62.
13.
ParhamDM. Pathologic classification of rhabdomyosarcomas and correlations with molecular studies. Mod Pathol2001;14:506–14.
14.
AkhtarMIqbalMA. Genetics of small round cell tumors of children. Ann Saudi Med1998;18:311–7.
15.
YanACChamlinSLLiangMG. Congenital infantile fibrosarcoma: A masquerader of ulcerated hemangioma. Pediatr Dermatol2006;23:330–4.
16.
FriedenIJ. Is it a hemangioma or could it be a cancer [editorial]?Pediatr Dermatol2006;23:402–3.
17.
Abdel-AalHHHabbibEEMsihrifMM. Rhabdomyosarcoma: The experience of the Pediatric Unit of Kasr El-Aini Center of Radiation Oncology and Nuclear Medicine (NEMROCK) (from January 1992 to January 2001). J Egypt Natl Canc Inst2006;18:51–60.
18.
WurmJConstantinidisJGranbenbauerGGIroH. Rhabdomyosarcomas of the nose and paranasal sinuses: Treatment results in 15 cases. Otolaryngol Head Neck Surg2005;133:42–50.
19.
HicksJFlaitzC. Rhabdomyosarcoma of the head and neck in children. Oral Oncol2002;38:450–9.
20.
LuuQCLaskyJLMooreTB. Treatment of embryonal rhabdomyosarcoma of the sinus and orbit with chemotherapy, radiation, and endoscopic surgery. J Pediatr Surg2006;41:15–7.
