Grenz ray therapy has declined in the United States during the past several decades with respect to availability, use, and resident training. However, it remains a simple, affordable, and effective option for managing several refractory dermatoses, especially psoriasis, hand eczema, and allergic contact dermatitis. Though high-dose grenz irradiation has been associated with the development of nonmelanoma skin cancers, grenz ray therapy is considered a safe treatment modality when administered according to the guidelines recommended herein. We review the value of grenz irradiation in contemporary dermatology.
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References
1.
BuckyG.Grenz ray therapy. New York, NY: Macmillan Co; 1929.
2.
CipollaroA, CrosslandP. X-rays and radium in the treatment of diseases of the skin. Philadelphia: Lea and Febiger;. 1967.
3.
EdwardsEK Jr, EdwardsEK, Sr. Grenz ray therapy. Int J Dermatol, 1990; 29:17-8.
4.
LindelofB. Grenz ray therapy in dermatology. An experimental, clinical and epidemiological study. Acta Derm Venereol Suppl (Stockh), 1987; 132:1-67.
5.
National Institute for Health and Clinical Excellence. Interventional procedure overview of Grenz rays therapy for inflammatory skin conditions. March. 2007. Available at: http://guidance.nice.org.uk/page.aspx?o=ip394consultation (accessed Aug20, 2007).
6.
KalzF. Observations on Grenz ray reactions. I. The response of normal human skin to Grenz rays. II. The effect of overdosage. Dermatologica, 1959; 118:357-71.
HollanderMB.Ultrasoft x-rays. An historical and critical review of the world experience with grenz rays and other x-rays of long wavelength. Baltimore (MD): Williams & Wilkins; 1968.
9.
LindelofB, LidenC, RosAM. Effect of grenz rays on Langerhans' cells in human epidermis. Acta Derm Venereol, 1984; 64:436-8.
10.
LindelofB, ForslindB. Electron microscopic observations of Langerhans' cells in human epidermis irradiated with grenz rays. Photodermatol, 1985; 2:367-71.
11.
LindelofB, LidenS, LagerholmB. The effect of grenz rays on the expression of allergic contact dermatitis in man. Scand J Immunol, 1985; 21:463-9.
12.
LindelofB, LindbergM. The effect of grenz rays on irritant skin reactions in man. Acta Derm Venereol, 1987; 67:128-32.
13.
RodelF, KeilholzL, HerrmannM, et al.Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int J Radiat Biol, 2007; 83:357-66.
14.
LindelofB.Grenz-ray therapy. In: GoldschmidtH, PanizzonRG, editors. Modern dermatologic radiation therapy. New York: Springer; 1991. p. 155-9.
15.
AroueteJ.Grenz ray therapy. In: SidiE, editor. Psoriasis. Springfield (IL): Charles C. Thomas; 1968. p. 243-57.
16.
HarberLC. Clinical evaluation of radiation therapy in psoriasis. Arch Dermatol, 1958; 77:554-8.
17.
BrodersonI, ReymannF. Effect of grenz rays on psoriasis treated with local corticosteroids. Dermatologica, 1981; 162:327-9.
18.
JohannessonA, LindelofB. The effect of grenz rays on psoriasis lesions of the scalp: a double blind bilateral trial. Photodermatol, 1985; 2:388-91.
19.
JohannessonA, LindelofB. Additional effect of grenz rays on psoriasis lesions of the scalp treated with topical corticosteroids. Dermatologica, 1987; 175:290-2.
20.
LindelofB, JohannessonA. Psoriasis of the scalp treated with Grenz rays or topical corticosteroid combined with Grenz rays. A comparative randomized trial. Br J Dermatol, 1988; 119:241-4.
21.
LindelofB. Psoriasis of the nails treated with grenz rays: a doubleblind bilateral trial. Acta Derm Venereol, 1989; 69:80-2.
22.
LindelofB, WrangsjoK, LidenS. A double-blind study ofGrenz ray therapy in chronic eczema of the hands. Br JDermatol. 1987 Jul; 117:77-80.
23.
CartwrightPH, RowellNR. Comparison of Grenz rays versus placebo in the treatment of hand eczema. Br J Dermatol, 1985; 112: 339-41.
24.
FairrisGM, JonesDH, MackDP, RowellNR. Conventional superficial X-ray versus Grenz ray therapy in the treatment of constitutional eczema of the hands. Br J Dermatol, 1985; 112:339-41.
25.
LindelofB, EklundG. Incidence of malignant skin tumors in 14,140 patients after grenz-ray treatment for benign skin disorders. Arch Dermatol, 1986; 122:1391-5.
DabskiK, StollHLJr. Skin cancer caused by grenz rays. J Surg Oncol, 1986; 31:87-93.
28.
MortensenAC, KjeldsenH. Carcinomas following Grenz ray treatment of benign dermatoses. Acta Derm Venereol, 1987; 67(6): 523-5.
29.
PanizzonRG.Radiation therapy of benign tumors, hyperplasias, and dermatoses. In: GoldschmidtH, PanizzonRG, editors. Modern dermatologic radiation therapy. New York: Springer; 1991. p. 139-45.
30.
GoldschmidtH. FDA recommendations on radiotherapy of benign diseases. J Derm Surg Oncol, 1978; 4:619-20.
31.
LindelofB, KarlbergJ, LyckefaltS, GerhardssonA. Grenz ray therapy: practical aspects of protecting office personnel from radiation. Photodermatol, 1988; 5:248-51.
32.
FrentzG, SorensenJL, FlodK. Nonmelanoma skin cancer of the scalp. On the etiology. Acta Derm Venereol, 1989; 69:142-6.
33.
WulfHC, BrodthagenH. Transmission of Bucky (Grenz) rays through human scalp hair. Acta Derm Venereol, 1977; 57: 525-7.
34.
WittenVH. The place of grenz radiation in dermatologic practice. Arch Dermatol, 1960; 81:110-25.
SchalockPC, CarterJC, ZugKA. Use of ionizing radiation in dermatologic training centers. J Am Acad Dermatol, 2006; 55: 912-3.
37.
SchalockPC, ZugKA, CarterJC, et al.Efficacy and patient perception of grenz ray therapy in the treatment of dermatoses refractory to other medical therapy. Dermatitis, 2008; 19:90-4.
