Studies are reviewed that address the question of whether anorexia nervosa is associated with abnormalities in central nervous system catecholamine metabolism. There is some support for the hypothesis that norepinephrine and dopamine metabolism are altered in this disorder.
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References
1.
RussellG. F. M., Anorexia Nervosa: Its Identity as an Illness and its Treatment, PriceJ. H. (ed.), Modern Trends in Psychological Medicine, 2, Butterworths, London, pp. 131–164, 1970.
2.
BoyarR. M.KatzJ.FinkelsteinJ. W., Anorexia Nervosa: Immatury of the 24-Hour Lutenizing Hormone Secretory Pattern, New. Engl. J. Med., 291, pp. 861–865, 1974.
3.
MecklenburgR. S.LoriauxD. L.ThompsonR. H., Hypothalamic Dysfunction in Patients with Anorexia Nervosa, Med., 53, pp, 147–159, 1974.
4.
FuxeK., Distribution of Monoamine Nerve Terminals in the Central Nervous System, Acta Physiol. Scand., 64, Suppl., 247, pp. 37–85, 1965.
5.
FuxeK., and HokfeltT., Histochemical Fluorescence Detection of Changes in Central Monamine Neurons Provoked by Drugs Acting on the CNS, Traingle, 10, pp. 73–84, 1971.
6.
HillarpN. A.FuxeK. and DahlstromA., Demonstration and Mapping of Central Neurons Containing Dopamine, Noradrenaline and 5-Hydroxy-tryptamine and Their Reactions to Psychopharmaca, Pharmacol. Rev., 18, pp. 727–741, 1966.
7.
GoldR. M., Hypothalamic Obesity: The Myth of the Ventromedical Nucleus, Sci., 182, pp. 488–490, 1973.
8.
MargulesD. L.LewisM. J.TragovichJ. A., Hypothalamic nor Epinephrine: Circadian Rhythms: The Control of Feeding Behavior, Sci., 178, pp. 640–642, 1971.
9.
LeibowitzS. F., Hypothalamic Beta-adernergic “Satiety System” Antagonizes an Alpha-adernergic “Hunger” System in the Rat, Nature, 226, pp. 963–964, 1970.
10.
OltmansG. A., and HarveyJ. A., LH Syndrome and Brain Catecholamine Levels after Lesions of the Nigrostriatal Bundle, Physiol. Beh., 8, p. 69, 1972.
11.
MawsonA. R., Anorexia Nervosa and the Regulation of Intake: A Review, Psychol. Med., 4, pp. 289–308, 1974.
12.
BarryV. C. and KalwansH. L., On the Role of Dopamine in the Pathophysiology of Anorexia Nervosa, J. Neural Trans., 38, pp. 107–122, 1976.
13.
MaasJ. W.FawcettJ. A. and DekirmenjianH., Catecholamine Metabolism, Depressive Illness, and Drug Response, Arch. Gen. Psychiat., 26, pp. 252–262, 1972.
14.
HalmiK. A.GoldbergS.EckertE.CasperR. and DavisJ., Pretreatment in Anorexia Nervosa, VigerskyR. A. (ed.), Anorexia Nervosa, Raven Press, New York, pp. 43–54, 1977.
15.
HalmiK. A.DekirmenjianH.DavisJ. M.CasperR., and GoldbergS., Catecholamine Metabolism in Anorexia Nervosa, Arch. Gen. Psychiat., 35, pp. 458–460, 1978.
16.
GrossH. A.LakeC. R.EbertM. A.SieglerM. G. and KopinI. J., Catecholamine Metabolism in Primary Anorexia Nervosa, J. Clin. Endocrinol. Metab., 49, pp. 805–809, 1979.