Premenstrual dysphoric disorder (PMDD), a menstruous dysfunction, is characterized by profoundly depressed mood, and studies have shown that antidepressants are effective for PMDD. The authors describe a case of PMDD who was initially treated with selective serotonin reuptake inhibitors. Due to intolerable gastrointestinal side effects with selective serotonin reuptake inhibitors, St. John's wort (900 mg/day) was substituted and much improvement in PMDD symptoms was noted for at least five-month follow-up. The authors propose that St. John's wort could be an alternative medication for PMDD, especially for patients experiencing intolerable side effects with selective serotonin reuptake inhibitors.
van LeusdenHA. Premenstrual syndrome no progesterone; Premenstrual dysphoric disorder no serotonin deficiency. Lancet1995;346:1443–1444.
2.
Di CarloGBorrelliFIzzoAAErnstE. St. John's wort: Prozac from the plant kingdom. Trends in Pharmacological Sciences2001;22:292–297.
3.
StevinsonCErnstE. A pilot study of Hypericum perforatum for the treatment of premenstrual syndrome. British Journal of Obstetrics and Gynaecology2000;107:870–876.
