The purpose of this article to describe a unique potential side effect of fluoxetine. A case report of a patient with post stroke depression treated with fluoxetine is presented. Fluoxetine was associated temporally with frequent short episodes of sexual excitement described by the patient as feeling like an orgasm. The relationship was dose dependent. Serotonergic medications, like fluoxetine, may induce sexual stimulation as a side effect. The mechanism for this effect is unclear but patients with organic brain disease may be at higher risk for this complication.
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2.
StevensonR. W. D.SolyomL., The Aphrodisiac Effect of Fenfluramine: Two Case Reports of a Possible Side Effect the Use of Fenfluramine in the Treatment of Bulimia, Journal of Clinical Psychopharmacology, 10:69–71, 1990.
3.
McCormickS.OlinJ.BrotmanA. W., Reversal of Fluoxetine-Induced Anorgasmia by Cyproheptadine in Two Patients, Journal of Clinical Psychiatry, 51:383–384, 1990.
4.
MaybergH.ParikhR.MorrisP. L. P., Spontaneous Remission of Post-stroke Depression and Temporal Changes in Cortical Serotonin S2 Receptors Measured by Positron Emission Tomography, Journal of Neuropsychiatry and Clinical Neuroscience, 3:30–83, 1991.
5.
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