Sexual dysfunction secondary to antidepressant drugs is an under-recognized clinical problem, and likely an important factor in noncompliance with treatment. We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.
Get full access to this article
View all access options for this article.
References
1.
MitchellJ. E. and PopkinM. K., Antidepressant Drug Therapy and Sexual Dysfunction in Men: A Review, Journal of Clinical Psychopharmacology, 3, pp. 76–79, 1983.
2.
RabkinJ. G.QuitkinF. M.McGrathP. J., Adverse Reactions to Monoamine Oxidase Inhibitors, Journal of Clinical Psychopharmacology, 5, pp. 2–9, 1985.
3.
HarrisonW. M.RabkinJ. G.EhrhardtA. A., Effects of Antidepressant Medication on Sexual Function: A Controlled Study, Journal of Clinical Psychopharmacology, 6, pp. 144–149, 1986.
4.
Couper-SmarttJ. D. and RodhamR., A Technique for Surveying Side Effects of Tricyclic Drugs with Reference to Reported Sexual Effects, Journal of International Medical Research, 1, pp. 473–476, 1973.
5.
KulikF. A. and WilburR., Case Report of Painful Ejaculation as a Side Effect of Amoxapine, American Journal of Psychiatry, 139, pp. 234–235, 1982.
6.
SimpsonG. M.BlairJ. H.IqbalJ., and IqbalF., A Preliminary Study of Trimipramine in Chronic Schizophrenia, Current Therapeutic Research, 8, pp. 225–231, 1966.
7.
SimpsonG. M.BlairJ. H., and AmusoD., Effects of Antidepressants on Genito-urinary Function, Diseases of the Nervous System, 26, pp. 787–789, 1965.
8.
BreierA.GinsbergE. M., and CharneyD. S., Seminal Emission Induced by Tricyclic Antidepressant, Letter, American Journal of Psychiatry, 141, pp. 610–611, 1984.
9.
RecklerJ. M., The Urologic Evaluation of Ejaculatory Disorders, in The Evaluation of Sexual Disorders, KaplanH. S. (ed.), Brunner/Mazel, New York, 1983.
10.
LevinR. J., The Physiology of Sexual Function in Women, Clinical Obstetrics and Gynecology, pp. 213–252, 1980.
11.
SovnerR., Anorgasmia Associated with Imipramine But not Desipramine: Case Report, Journal of Clinical Psychiatry, 44, pp. 345–346, 1983.
12.
SovnerR., Treatment of Tricyclic Antidepressant-induced Orgasmic Inhibition with Cyproheptadine, Journal of Clinical Psychopharmacology, 4, p. 169, 1984.
13.
SchoonoverS. C., Depression, in The Practitioner's Guide to Psychoactive Drugs, 2nd Edition, BassukE. L.SchoonoverS. C., and GelenbergA. J. (eds.), Plenum, New York, 1983.
