Currently popular methodologies in life changes and illness research are presented in some detail. Selected examples of epidemiological studies utilizing these methodologies are briefly reviewed. Examples of both retrospective and prospective investigations of life change and illness are given. Discussed in the chapter are the author's views as to limitations of the epidemiologic method and probable directions of future research in efforts to clarify etiologic mechanisms along the pathway between subjects' recent life changes and their subsequent susceptibility to illness.
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