With increasing depression a patient's Parkinsonian tremors increased. With successful treatment of the patient's depression with Imipramine, the tremors disappeared, but slowly began again after drug noncompliance resulted in recurrence of depression. Evidence suggesting a relationship between depression and extrapyramidal dysfunction is discussed. The need for a greater understanding of the role of the extrapyramidal system in emotion and behavior and the connections between the extrapyramidal system to limbic and cortical structures are noted.
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