Studies of patterns of lutenizing hormone (LH) secretion in anorexia nervosa are reviewed. Restoration of ideal weight is not always associated with return to adult circadian LH secretion patterns. Abnormalities in LH secretion (immature patterns) may represent a biological “marker” of active anorexia nervosa.
Get full access to this article
View all access options for this article.
References
1.
FrischR. E. and RevelleR., Height and Weight at Menarche and a Hypothesis of Critical Body Weights and Adolescent Events, Science, 169, pp. 397–398, 1970.
2.
FrischF. E. and McArthurJ., Menstrual Cycles: Fatness as Determinant of Minimal Weight for Height Necessary for Their Maintenance or Onset, Science, 185, pp. 949–951, 1974.
3.
LeRoyL. E., Famine Amenorrhea (Seventeenth-Twentieth Centuries), Ann. ESC, 24, pp. 1589–1601, 1969.
4.
CrispA. H. and StonehillE., Relation Between Aspects of Nutritional Disturbance and Menstrual Activity in Primary Anorexia Nervosa, Brit. Med. J., 3, pp. 149–151, 1971.
5.
KayD. W. K. and LeighD., Naturan History, Treatment, and Prognosis of Anorexia Nervosa, Based on a Study of 38 Patients, J. Ment. Sci., 100, pp. 411–431, 1954.
6.
HalmiK. A., Anorexia Nervosa: Demographic and Clinical Features in 94 Cases, Psychosom. Med., 36, pp. 18–26, 1974.
7.
BellE. T.HarknessR. A.LoraineJ. A. and RussellG. F. M., Hormone Assay Studies in Patients with Anorexia Nervosa, Acta. Endocrinol. (Kbh), 51, pp. 140–148, 1966.
8.
RussellG. F. M., Psychological and Nutritional Factors in Disturbance of Menstrual Function and Ovulation, Postgrad. Med. J., 48, pp. 10–13, 1972.
9.
KatzJ. L.BoyarR. M.WeinerH.GorynskiG.RoffwargH., and HellmanL., Toward an Elucidation of the Psychoendocrinology of Anorexia Nervosa, SacharE. (ed.), Hormones, Behavior, and Psychopathology, Raven Press, New York, pp. 263–283, 1976.
10.
BoyarR. M.KatzJ.FinkelsteinJ. W.KapenS.WeinerH.WeitzmanE. D. and HellmanL., Anorexia Nervosa: Immaturity of the 24-Hour Luteinizing Hormone Secretory Pattern, New Engl. J. Med., 291, pp. 861–865, 1974.
11.
BrownG. M.GarfinkelP. E.JeuniewicN. and StancerH. C., Endocrine Profiles in Anorexia Nervosa, VigerskyR. (ed.), Anorexia Nervosa, Raven Press, New York, pp. 123–135, 1977.
12.
HellmanL.NakadaF.CurtiJ.WeitzmanE.KreamJ.RoffwargH.EllmanS.FukushimaK. and GallagherT. F., Cortisol is Secreted Episodically by Norman Man, J. Clini Endocrinol. Metabl., 30, pp. 411–422, 1970.
13.
FeighnerJ. P.RobinsE.GuzeS. B.WoodruffR. A.Jr.WinokurG. and MunozR., Diagnostic Criteria for Use in Psychiatric Research, Arch. Gen. Psychiat., 26, pp. 57–63, 1972.
14.
MidgleyA. R.Jr., Radioimmunoassay: A Method for Human Chorionic Gonadotropin and Human Luteinizing Hormone, Endocrinology, 79, pp. 10–18, 1966.
15.
BoyarR.PerlowM.HellmanL.KapenS. and WeitzmanE., Twenty-Four Patterns of Luteinizing Hormone Secretion in Normal Men with Sleep Stage Monitoring, J. Clin. Endocrinol. Metab., 35, pp. 73–81, 1972.
16.
KatzJ. L.BoyarR. N.RoffwargH.HellmanL. and WeinerH., LHRH Responsiveness in Anorexia Nervosa: Intactness Despite Prepubertal Cricadian LH Pattern, Psychosom. Med., 39, pp. 241–251, 1977.
17.
BeumontP. J. V.GeorgeG. C. W.PimstoneB. L. and VinikA. I., Body Weight and the Pituitary Response to Hypothalamic Releasing Hormones in Patients with Anorexia Nervosa, J. Clin. Endocrinol. Metab., 43, pp. 487–496, 1976.
18.
WarrenM. P. and WieleVande R. L., Clinical and Metabolic Features of Anorexia Nervosa, Amer. J. Obstet. Gynecol, 117, pp. 435–449, 1973.
19.
MecklenburgR. S.LoriauxD. L.ThompsonR. H. and LipsettM., Hypothalamic Dysfunction in Patients with Anorexia Nervosa, Medicine, 53, (Baltimore), pp. 147–159, 1974.
20.
WiegelmannW. and SolbachH. G., Effects of LH-RH on Plasma Levels of LH and FSH in Anorexia Nervosa, Horm. Metab. Res., 4, pp. 404, 1972.
21.
YoshimotoY.MorideraK., and ImuraH., Restoration of Normal Pituitary Gonadotropin Reserve by Administration of Luteinizing Hormone-Releasing Hormone in Patients with Hypogonadotropic Hypogonadism, New Engl. J. Med., 292, pp. 242–245, 1975.
22.
WurtmanR. J. and FernstromJ. D., Control of Brain Neurotransmitter Synthesis by Precursor Availability and Nutritional State, Biochem. Pharmacol.25, pp. 1691–1696, 1976.