This is a report on a male patient with a previous history of psychotic disorder who was arrested for arson. During the following hospitalization in a psychiatric unit, a genetic syndrome, namely Klinefelter syndrome (47,XXY), was diagnosed. The association between fire-setting behavior and Klinefelter syndrome is reviewed, and the underlying explanatory hypothesis is discussed.
SmythCMBremnerWJ. Klinefelter syndrome. Archives of Internal Medicine1998;158(12):1309–1314.
2.
Psychiatric disorders in relation to Klinefelter's syndrome. BandmannHJBreitR, eds. Heidelberg, West Germany: Springer-Verlag; 1984:192–201.
3.
DervauxAArtigesE. Olanzapine for violent schizophrenia and Klinefelter syndrome. American Journal of Psychiatry2002;159(3):493–494.
4.
SalbenblattJAMeyersDCBenderBGLindenMGRobinsonA. Gross and fine motor development in 47,XXY and 47,XYY males. Pediatrics1987;80(2):240–244.
5.
BoillotFBlamoutierACarliozH. Irreductible congenital dislocation of the hip at birth. Archives de Pédiatrie1996;3(2):117–121.
6.
MillerMESulkesS. Fire-setting behavior in individuals with Klinefelter syndrome. Pediatrics1988;82(1):115–117.
7.
NielsenJPelsenBSorensenK. Follow-up of 30 Klinefelter males treated with testosterone. Clinical Genetics1988;33(4):262–269.
8.
GeschwindDHBooneKBMillerBLSwerdloffRS. Neurobehavioral phenotype of Klinefelter syndrome. Mental Retardation and Developmental Disabilities Research Reviews2000;6(2):107–116.
9.
WarwickMMDoodyGALawrieSMKestelmanJNBestJJJohnstoneEC. Volumetric magnetic resonance imaging study of the brain in subjects with sex chromosome aneuploidies. Journal of Neurology and Neurosurgery Psychiatry1999;66(5):628–632.
10.
PatwardhanAJEliezSBenderBLindenMGReissAL. Brain morphology in Klinefelter syndrome: Extra X chromosome and testosterone supplementation. Neurology2000;54(12):2218–2223.
11.
PrallJAMcGavranLGreffeBSPartingtonMD. Intracranial malignant germ cell tumor and the Klinefelter syndrome. Case report and review of the literature. Pediatric Neurosurgery1995;23(4):219–224.
