The hypothesis that upper airway breathing behaviors generally follow the rules of a physiologic regulating system implies the existence of sensors that monitor the airway environment. The purpose of this study was to assess the sensitivity of the monitoring system to sudden changes in airway patency in healthy, adult subjects. An instrument capable of changing airway dimensions in about 10 ms was used to assess psychophysical recognition and physiologic responses to sudden changes in airway size. Our results indicate that psychophysical recognition of change in patency occurred at a mean constriction area of 0.31 cm2. These findings suggest that recognition of change in airway size occurs well before the airway becomes flow-limiting or severely obstructed.
BrobeckJRYamamotoW.S.Exchange, control and regulation. In: Physiological controls and regulations.Philadelphia: WB Saunders,1965.
2.
FurusawaK., YamaokaM., IchikawaN., KumaiT.Airflow receptors in the lip and buccal mucosa.Brain Res Bull1992; 29: 69–74.
3.
GandeviaS.C., KillianK.J., CampbellE.J.M.The contribution of upper airway and inspiratory muscle mechanisms to the detection of pressure changes in the mouth in normal subjects.Clin Sci1981; 60: 513–518.
4.
GrodinsF.S.Buell J, Bart AJ. Mathematical analysis and digital simulation of the respiratory control system.J Appl Psychol1967; 22: 260–276.
5.
KillianK.J., CampbellE.J.M., HowellJ.B.L.The effect of increased ventilation on resistive load discrimination.Am Rev Respir Dis1979; 120: 1233–1238.
6.
KillianK.J., ManhutteC.K., CampbellE.J.M.Magnitude scaling of externally added loads to breathing.Am Rev Respir Dis1981; 123: 12–15.
7.
KillianK.J., ManhutteC.K., HowellJ.B.L., CampbellE.J.M.Effect of timing, flow, lung volume, and threshold pressures on resistive load detection.J Appl Physiol1980; 49: 958–963.
8.
LaineM.T., WarrenD.W.Perceptual and respiratory responses to added nasal airway resistance loads in older adults.Laryngoscope1995; 105: 425–428.
9.
Linder-AronsonS.Adenoids: their effect on mode of breathing and nasal airflow and their relationship to characteristics of the facial skeleton and the dentition.Acta Otolaryngol Suppl1979; 265: 1–132.
10.
McBrideB., WhitelawW.A.A physiological stimulus to upper airway receptors in humans.J Appl Physiol1981; 51: 1179–1189.
11.
QuinnG.W.Are dentofacial deformities a preventable disease?N C Dent J1978; 61: 5–6.
12.
RubinR.M.Facial deformity: a preventable disease?Angle Orthod1979; 49: 98–103.
13.
Sant'AmbrogioG.Information arising from the tracheobronchial tree in mammals.Physiol Rev1982; 62: 531–569.
14.
Sant'AmbrogioG., MatthewO.P., FisherJ.T., Sant'AmbrogioF.B.Laryngeal receptors responding to transmural pressure, airflow, and local muscle activity.J Respir Physiol1983; 54: 317–330.
15.
SarhanN.A., CarsonE.R., SaundersK.B.Mathematical modeling and computer simulation of the control system regulating breathing and its pattern in man. In: WippB.J., WilbergD.M. eds. Modeling and control breathing.New York: Elsevier, 1982; 293–306.
16.
SaundersK.B., BaliH.N., CarsonE.R.A breathing model of the respiratory system: the controlled system.J Theor Biol1980; 84: 135–161.
WarrenD.W., HairfieldW.M., SeatonD., HintonV.A.The relationship between nasal airway size and nasal airway resistance, Am J Orthod Dentofacial Orthop1987a; 92: 390–395.
20.
WarrenD.W., HairfieldW.M., SeatonD., HintonV.A.Relationship between size of the nasal airway and nasal-oral breathing.Am J Orthod Dentofacial Orthop1988; 93: 289–293.
21.
WarrenD.W., HintonV.A., PillsburvH.C., HairfieldW.M.Effects of size of the nasal airway on nasal airflow rate, Arch Otolaryngol1987b; 113: 405–408.
22.
WileyR.L., ZechmanF.W.Perception of added airflow resistance in humans.Respir Physiol1966; 2: 73–87.
23.
ZechmanF.W., DavenportP.W.Temporal differences in the detection of resistive and elastic loads to breathing.Respir Physiol1978; 34: 267–277.
24.
ZechmanF.W., WileyR.L.Afferent inputs to breathing: respiratory sensation. In: CherniackN.S., WiddicombeJ.C. eds. Handbook on physiology: the respiratory system. Am Physiol Soc.Baltimore: Williams & Wilkins, 1986; 449–474.
