Some clefts of the lip and palate appear to result from the rupture after fusion has occurred. This possibility is suggested by (1) epithelial remnants found in the palatal shelves, (2) regenerating epithelium found in the palatal clefts of human fetuses older than 13 weeks, (3) immature epithelium visible on the margin of the cleft, (4) nasopalatine ducts cut off by clefts, (5) perforation type cleft found in the hard palate, (6) a Simonart band visible in six cleft mouse fetuses, (7) duplicated upper lateral incisors enclosing a lip-jaw cleft, and (8) rodent cavities in the lip or palate related to cleft formation.
De Forest-HaightM., StarkR.B.. (1968). Investigation of possible causative factors producing cleft lip and cleft palate. In: LongacreJ.J., ed. Craniofacial anomalies.Philadelphia: Lippincott, 57–60.
7.
FelberP.. (1919). Anlage und Entwicklung des Maxillare und Premaxillare beim Menschen.Morphol Jahrb50: 451–499.
8.
FermV.H., KilhamL.. (1964). Congenital anomalies induced in hamster embryos with H-1 virus.Science145: 510–511.
9.
FleischmannA.. (1937). Neue Erfahrungen mit Gesichtsspalten bei Menschen und Tiere.Sitz Phys Med Soz Erlangn69: 315–324.
10.
FraserF.C.. (1961). The use of teratogens in the analysis of abnormal developmental mechanisms. First International Conference on Congenital Malformations. London. Philadelphia: Lippincott.
11.
GlasstoneS.. (1963). Regulative changes in tooth germs grown in tissue culture.J Dent Res42: 1364–1368.
12.
HerbstE., ApfelstaedtM.. (1930). Malformations of the jaws and teeth.London: Oxford University Press.
13.
HisW.. (1901). Beobachtungen zur Geschichte der Nasen- und Gaumenbildung beim menschlichen Embryo.Abhdl Math-Phys Säch Ges Wissen27: 349–389.
14.
InouyeM.. (1912). Der Zwischenkiefer, seine Entstehung und der Verlauf der Hasenscharten-kieferspalte und der schrägen Gesichtsspalte.Anat Hefte45: 475–600.
15.
JarmerK.. (1922). Über die mehrfache Anlage des Zwischenkiefers beim Menschen.Z Anat64: 56–75.
KeithA.. (1913). Cited from Brophy TW. Oral surgery, a treatise on the disease, injuries and malformations of the mouth and associated parts.Philadelphia: Blakiston & Son, 1917: 506–736.
18.
KitamuraH., KrausB.S.. (1964). Visceral variations and defects associated with cleft lip and palate in human fetuses: a macroscopic description.Cleft Palate J1: 99–115.
19.
KitamuraH.. (1972). Variations in cleft lip and palate in the human abortus: an analysis according to the remanis of the nasopalatine duct and of the fused epithelial margins of the palatal shelves.Bull Kanagawa Dent Col1: 28–44.
20.
KitamuraH.. (1978). Mechanism of cleft lip and palate in A/Jax and CL/Fr strain mice.Bull Kanagawa Dent Col6: 55–75.
21.
KitamuraH., KoizumiM.. (1986). Development of the halved tooth grafts: a study on the mechanism of duplicated or supernumerary teeth formation.Bull Kanagawa Dent Col14: 37–43.
22.
KitamuraH., TsuzukiH.. (1974). Variations in cleft lip and palate in CL/Fr strain mouse fetuses.Bull Kanagawa Dent Col2: 11–22.
23.
KoellikerT.H.. (1882). Über das os intermaxillare des Menschen.Nova Acta Carol Akad Naturforschen43: 372–395.
24.
KreshoverS.J., CloughO.W., BearD.M.. (1958). A study of prenatal influences on tooth development in humans.J Am Dent Assoc56: 230–247.
25.
LynchL.B., LewisS.R., BlockerT.G.Jr. (1966). Cleft palate not explained by embryology.Plast Reconstr Surg38: 552–554.
26.
OhashiY.. (1964). A study on the location of cleft related to hypodontia or hyperdontia in lip-jaw-palate cases.Nippon Koku-Kagaku-Kaishi20: 401–422.
27.
PeterK.. (1913). Atlas der entwicklung der nase und das Gaumens beim Menschen mit Einschluss der Entwicklungsstörungen.Jena: Fisher, 99.
28.
PeterK.. (1914). Über die funktionelle Bedeutung der sogenannten “Epithelperlen” am harten Gaumen von Feten und Kindern.Dtsch Med Wochenschr11: 649.
29.
SchaefferJ.P.. (1920). The nose, paranasal sinuses, nasolacrimal passageways, and olfactory organ in man.Philadelphia: Blakiston & Son, 51–57.
30.
Schumachers. (1927). Die Mundhöhle. In: MoellendorfW., ed. Handbuch der mikroskopischen Anatomie des Menschen.Berlin: Springer.
31.
SchuepbachP.M.. (1983). Experimental induction of an incomplete hard-palate cleft in the rat.Oral Surg55: 2–9.
32.
SchuepbachP.M., Doerig-SchwarzenbachA.G., SchroederH.E.. (1984). Rare total and partial palatal clefts experimentally induced in the rat.Cleft Palate J21: 204–218.
33.
SchuepbachP.M., SchroederH.E.. (1985). Unilateral clefts: a new defect of the rat secondary palate.J Craniofacial Genet Develop Biol5: 21–30.
34.
ScottJ.H.. (1955). The early development of oral cysts in man.Br Dem J98: 109–114.
35.
SicherH.. (1962). Anatomy and oral pathology.Oral Surg15: 1264–1269.
36.
SmileyG.R.. (1972). A possible genesis for cleft palate formation.Plast Reconstr Surg50: 390–394.
37.
StarkR.B., EhrmannN.A.. (1958). The development of the center of the face with particular reference to surgical correction of bilateral cleft lip.Plast Reconstr Surg21: 177–192.
38.
SteinigerF.. (1942a). Über Hasenschartenzysten.Z Menschl Vererb Konstitut-Lehre25: 1–27.
39.
SteinigerF.. (1942b). Über Hasenschartenzysten und -brücken bei neugeborenen Mäusen.Z Menschl Vererb Konstitut-Lehre25: 571–581.
40.
StreeterG.L.. (1920). Weight, sitting height, head size, foot length and menstrual age of the human embryo.Contrib Embryol11: 143–170.
41.
StreeterG.L.. (1948). Developmental horizons in human embryos, description of age groups XV, XVI, XVII and XVIII.Contrib Embryol32: 133–204.
42.
StreeterG.L.. (1951). Developmental horizons in human embryos, description of age groups XIX, XX, XXII and XXIII.Contrib Embryol34: 165–196.
43.
ToenduryG.. (1961). On the mechanism of cleft formation. In: PruzanskyS., ed. Congenital anomalies of the face and associated structures.Springfield: CC Thomas 1961: 85.
44.
ToenduryG.. (1962). Embryopathie, über die Wirkungsweise (Infektionsweg und Pathogenese) von Viren auf den Menschlichen Keimling, Pathologie und Klinik in Einzeldarstellungen.Berlin: Springer.
45.
TraslerD.G., ClarkK.H., FraserF.C.. (1956). No cleft palate in offsprings of pregnant mice given cortisone after fetal palatal closure.J Hered47: 99–100.
46.
VeauV.. (1931). Division Palatine.Paris: Masson et Cie.
47.
VeauV.. (1934). Le Squelette du bec-de-lièvre.Ann Anal Path11: 873–904.
48.
VeauV.. (1938). Hasenscharten menschlicher Keimlinge auf der Stufe 21–23 mm SSL.Z Anat Entw-gesch108: 459–493.
49.
AngeliciD.R.. (1968). Reopening of fused palatal shelves.Cleft Palate J5: 205–210.
50.
ArdingerH.H., BütowK.H., BellG.I., BardachJ., VanDemarkD.R., MurrayJ.C.. (1989). Association of genetic variation of the transforming growth factor-alpha gene with cleft lip and palate.Am J Hum Genet45: 349–353.
51.
ChungC.S., BixlerD., WatanabeT., KoguchiH., Foch-AndersonP.. (1986). Segregation analysis of cleft lip with or without cleft palate: a comparison of Danish and Japanese data.Am J Hum Genet39: 603–611.
52.
DenckerL., PrattR.M.. (1981). Association of the presence of the Ah receptor in embryonic tissues from mice sensitive to TCDD-induced cleft palate.Teratogenesis Carcinog Mutagen1: 399–406.
53.
DiewertV.M., ShotaK.. (1990). Morphological observations in normal and primary palate and cleft lip embryos in the Kyoto collection.Teratology41: 663–677.
54.
JohnstonM.C., BronskyP.T., MillicovskyG.. (1990). Embryogenesis of cleft lip and palate. In: McCarthyJ., ed. Plastic surgery.Philadelphia: WB Saunders, 2515–2552.
55.
KitamuraH.. (1966). Epithelial remnants and pearls in the secondary palate in the human abortus: a contribution to the study of the mechanism of cleft palate formation.Cleft Palate J3: 240–257.
56.
MatoM., AikawaE., SmileyG.R.. (1972). Invagination of human palatal epithelium prior to contact.Cleft Palate J9: 335–340.
57.
MillicovskyG., JohnstonM.C.. (1981). Hyperoxia and hypoxia in pregnancy: simple experimental manipulation alters the incidence of cleft lip and palate in CL/Fr mice.Proc Natl Acad Sci USA78: 5722–5723.
58.
WatermanR.E., MellerS.E.. (1974). Alterations in the epithelial surface of human palatal shelves prior to and during fusion: a scanning electron microscopic study.Anat Rec180: 111–135.
