Marfan syndrome (MFS) is caused by abnormal systemic connective tissue. The main clinical manifestations include long limbs, long slender fingers, lens subluxation, abnormal cardiac valves, and aortic aneurysm. We report the case of an 11-year-old patient with MFS who underwent orthodontic treatment and was followed up until the age of 25 years. We found no significant differences in tooth movement between the patient with MFS and healthy subjects. However, because patients with MFS show characteristic facial growth and an increased risk of developing systemic comorbidities, their dental status requires careful observation over time.
BilodeauJ.E.Retreatment of a patient with Marfan syndrome and severe root resorption.Am J Orthod Dentofacial Orthop.2010; 137: 123–134.
2.
CrosherR., HolmesA.Marfan syndrome: dental problems and management.Dental Update.1988; 15: 120–122.
3.
De CosterP., De PauwG., MartensL., De PaepeA.Craniofacial structure in Marfan syndrome: a cephalometric study.Am J Med Genet A.2004; 131: 240–248.
4.
De CosterP.J., MartensL.C., De PaepeA.Oral manifestations of patients with Marfan syndrome: a case-control study.Oral Surg Oral Med Oral Pathol Oral Radiol Endod.2002; 93: 564–572.
5.
De PaepeA., DevereuxR.B., DietzH.C., HennekamR.C., PyeritzR.E.Revised diagnostic criteria for the Marfan syndrome.Am J Med Genet.1996; 62: 417–426.
DocimoR.M.P., D'AuriaF., GregoS., CostacurtaM., PerugiaC., ChiarielloL.Association between oro-facial defects and systemic alterations in children affected by Marfan syndrome.J Clin Diagn Res.2013; 7: 700–703.
9.
GiganteA., ChillemiC., GrecoF.Changes of elastic fibers in musculoskeletal tissues of Marfan syndrome: a possible mechanism of joint laxity and skeletal overgrowth.J Pediatr Orthop.1999; 19: 283–288.
10.
GuntherothW.G.How important are dental procedures as a cause of infective endocarditis?Am J Cardiol.1984; 54: 797–801.
11.
HammarstromL., BlomlofL., LindskogS.Dynamics of dentoalveolar ankylosis and associated root resorption.Endod Dent Traumatol.1989; 5: 163–175.
12.
HayamiT., ZhangQ., KapilaY., KapilaS.Dexamethasone's enhancement of osteoblastic markers in human periodontal ligament cells is associated with inhibition of collagenase expression.Bone.2007; 40: 93–104.
13.
IizukaT., IshikawaF.Normal standards for various cephalometric analysis in Japanese adults.Jpn J Orthod.1957; 16: 4–12.
14.
KatoC., KojimaT., KomakiM., MimoriK., DuarteW.R., TakenagaK., IshikawaI.S100A4 inhibition by RNAi up-regulates osteoblast related genes in periodontal ligament cells.Biochem Biophys Res Commun.2005; 326: 147–153.
15.
KhonsariR.H., CorreP., Boukerma-VernexZ., SchmidtJ., RenaudinK., FraysseC., Gayet-DelacroixM., Khau Van KienP., DavidA.Extreme oral manifestations in a Marfan-type syndrome.Int J Oral Maxillofac Surg.2010; 39: 622–625.
16.
Morales-ChavezM.C., Rodriguez-LopezM.V.Dental treatment of Marfan syndrome. with regard to a case.Med Oral Patol Oral Cir Bucal.2010; 15: e859–e862.
17.
PanzariniS.R., GulinelliJ.L., PoiW.R., SonodaC.K., PedriniD., BrandiniD.A.Treatment of root surface in delayed tooth replantation: a review of literature.Dent Traumatol.2008; 24: 277–282.
18.
PanzariniS.R., OkamotoR., PoiW.R., SonodaC.K., PedriniD., da SilvaP.E., SaitoC.T., MaraoH.F., SedlacekP.Histological and immunohistochemical analyses of the chronology of healing process after immediate tooth replantation in incisor rat teeth.Dent Traumatol.2013; 29: 15–22.
19.
PooleA.E.Craniofacial aspects of the Marfan syndrome.Birth Defects Orig Artic Ser.1989; 25(4): 73–81.
20.
RaoulH., JudithA., IanK.Well-known miscellaneous syndromes.Gorlin's Syndrome of the Head and Neck.5th ed.New York: Oxford University Press; 2010: 1283–1289.
21.
SaitoM., KurokawaM., OdaM., OshimaM., TsutsuiK., KosakaK., NakaoK., OgawaM., ManabeR., SudaN.. ADAMTSL6beta protein rescues fibrillin-1 microfibril disorder in a Marfan syndrome mouse model through the promotion of fibrillin-1 assembly.J Biol Chem.2011; 286: 38602–38613.
22.
ShigaM., KapilaY.L., ZhangQ., HayamiT., KapilaS.Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype.J Bone Miner Res.2003; 18: 67–77.
23.
ShigaM., SaitoM., HattoriM., ToriiC., KosakiK., KiyonoT., SudaN.Characteristic phenotype of immortalized periodontal cells isolated from a Marfan syndrome type I patient.Cell Tissue Res.2008; 331: 461–472.
24.
StraubA.M., GrahameR., ScullyC., TonettiM.S.Severe periodontitis in Marfan's syndrome: a case report.J Periodontol.2002; 73: 823–826.
25.
StromB.L., AbrutynE., BerlinJ.A., KinmanJ.L., FeldmanR.S., StolleyP.D., LevisonM.E., KorzeniowskiO.M., KayeD.Dental and cardiac risk factors for infective endocarditis. A population-based, case- control study.Ann Intern Med.1998; 129: 761–769.
26.
SudaN., MoriyamaK., GanburgedG.Effect of angiotensin II receptor blocker on experimental periodontitis in a mouse model of Marfan syndrome.Infect Immun.2013; 81: 182–188.
27.
SudaN., ShigaM., GanburgedG., MoriyamaK.Marfan syndrome and its disorder in periodontal tissues.J Exp Zool B Mol Dev Evol.2009; 312B: 503–509.
WestlingL., MohlinB., BresinA.Craniofacial manifestations in the Marfan syndrome: palatal dimensions and a comparative cephalometric analysis.J Craniofac Genet Dev Biol.1998; 18: 211–218.
30.
WolfM., LossdorferS., AbuduwaliN., MeyerR., KebirS., GotzW., JagerA.In vivo differentiation of human periodontal ligament cells leads to formation of dental hard tissue.J Orofac Orthop.2013; 74: 494–505.
