Abstract
Objective
To assess the effect of tranexamic acid on the quality of the surgical field.
Design
Prospective, randomized, double-blind study.
Setting
Institutional, tertiary referral hospital.
Participants
American Society of Anesthesiologists physical status class I patients, aged 8 to 60 months with Group II or III (Balakrishnan's classification) clefts scheduled for cleft palate repair.
Interventions
Children were randomized into two groups. The control group received saline, and the tranexamic acid group received tranexamic acid 10 mg/kg as a bolus, 15 minutes before incision.
Main Outcome Measures
Grade of surgical field on a 10-point scale, surgeon satisfaction, and primary hemorrhage.
Results
Significant improvements were noted in surgeon satisfaction and median grade of assessment of the surgical field (4 [interquartile range, 4 to 6] in the control group vs. 3 [interquartile range, 2 to 4] in the test group; P = .003) in the tranexamic acid group compared to the control group.
Conclusion
Preincision administration of 10 mg/kg of tranexamic acid significantly improved the surgical field during cleft palate repair.
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