To resolve if TBX22 mutations cause isolated tongue-tie in the Finnish population.
Design
Mutation analysis of the coding region of the TBX22 gene in 50 Finnish isolated tongue-tie patients and 61 control samples.
Results
One putative sequence variation was identified from two male patients, but whether this represents a polymorphism or causative mutation remains unknown.
Conclusions
Mutations in the coding region of the TBX22 gene are not a major cause of aankyloglossia in the Finnish population and do not explain the sex difference or inheritance of tongue-tie.
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