Binder syndrome is a malformative midfacial alteration, known also as maxillonasal dysplasia or maxillonasal dysostosis. In this article, two cases of affected patients are reported, and the features of the condition are reviewed. One case presents a cleft lip. Hypotheses about etiology, pathogenesis, and classification of the syndrome are illustrated. This work provides a contribution for the delineation of a differential diagnostic procedure.
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