Congenital fenestration of the secondary palate is the rarest type of facial cleft. Of the 26 putative cases in the literature, only 5 had confirmation of the cleft during the neonatal period. This report documents such a cleft in an infant and presents the likely pathogenesis.
BurdiA.R.. Distribution of midpalatine cysts: a reevaluation of human palatal closure mechanisms.J Oral Surg.1968; 26: 41–45.
2.
BurdiA.R., FaistK.. Morphogenesis of the palate in normal human embryos with special emphasis on the mechanisms involved.Am J Anat.1967; 120: 149–159.
3.
BurdittD.N., WaterfieldJ.N., ShawR.M.. Vertical development of the secondary palate in hamster embryos following exposure to 6-mercaptopurine.Teratology.1988; 37: 591–598.
FergusonM.W.J., HonigL.S.. Epithelial-mesenchymal interactions during vertebrate palatogenesis.Curr Top Dev Biol.1984; 19: 137–164.
12.
GehrisA.L., GreeneR.M.. Regulation of murine embryonic epithelial cell differentiation by transforming growth factors beta.Differentiation.1992; 49: 167–173.
13.
JezewskiP., VieiraA.R., NishimuraC., LudwigB., JohnsonM., O'BrienS.E., Daack-HirschS., SchultzR.E., WeberA., NepomucenaB., Romitti PA ChristensenK., OrioliI.M., CastillaE.E., MachidaJ., NatsumeN., MurrayJ.C.. Complete sequencing demonstrates a role for Msx1 in nonsyndromic cleft lip and palate.J Med Genet.2003; 40: 399–407.
14.
KochW.E., SmileyG.R.. In vivo and in vitro studies of the development of the avian secondary palate.Arch Oral Biol.1981; 26: 181–187.
15.
KondoS., SchutteB.C., RichardsonR.J., BjorkB.C., KnightA.S., WatanabeY., HowardE., de LimaR.L., Daack-HirschS., SanderA., McDonald-McGinnDM, ZackaiE.H., LammerE.J., AylsworthA.S., ArdingerH.H., LidralA.C., PoberB.R., MorenoL., Arcos-BurgosM., ValenciaC., HoudayerC., BahuauM., Moretti-FerreiraD., Richieri-CostaA., DixonM.J., MurrayJ.C.. Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.Nat Genet.2002; 32: 285–289.
16.
LynchJ.B., LewisS.R., BlockerT.G.. Cleft palate not explained by embryology.Plast Reconstr Surg.1966; 38: 552–554.
17.
MalekF.A., MortitzK.U., FanghanelJ., BienengraberV.. Sex-related differences in procarbazine-induced cleft palate and microgenia and the anti-teratogenic effect of prenatal folic acid supplementation in rats.Ann Anat.2003; 185: 465–470.
18.
MehendaleF.V., SommerladB.C.. Submucous cleft palates presenting with a perforation.Cleft Palate Craniofac J.2003; 40: 203–206.
19.
MetcalfC.. Two palatal anomalies.Boston Med Surg J.1908; 159: 409–410.
20.
MittsT.F., GarrettW.S., HurwitzD.J.. Cleft of the hard palate with soft palate integrity.Cleft Palate J.1981; 18: 204–206.
RouxJ.P.. Congenital fissure of the soft palate.Lancet.1835; 1: 694–695.
26.
SatokataL., MaasR.. Msx-1 deficient mice exhibit cleft palate and abnormalities of craniofacial and tooth development.Nat Genet.1994; 6: 348–356.
27.
SchüpbachP.M.. Experimental induction of an incomplete hard palate cleft in the rat.Oral Surg.1983; 55: 2–9.
28.
SchüpbachP.M., SchroederH.E.. Prenatal repair of experimentally induced clefts in the secondary palate of the rat.Teratology.1984; 30: 131–142.
29.
ShulerC.F.. Programmed cell death and cell transformation in craniofacial development.Crit Rev Oral Biol Med.1995; 6: 202–217.
30.
SmileyG.R.. A possible genesis for cleft palate formation.Plast Reconstr Surg.1972; 50: 390–394.
31.
SperberG.H.. Palatogenesis: closure of the secondary palate. In: WyszinskiD.F., ed. Cleft Lip and Palate: From Origin to Treatment.Oxford: Oxford University Press;2002: 14–24.
TrelatU.. Imperfect intonation and its causes.Lancet.1870; 553.
34.
VeauV.. Division Palatine.Paris: Masson et Cie;1931.
35.
Von BergmannE.. A System of Practical Surgery. Vol. 1. New York: Lea Brothers;1904: 447.
36.
WatermanR.E., MellerS.M.. Alterations in the epithelial surface of human palatal shelves prior to and during fusion: a scanning microscopy study.Anat Rec.1974; 180: 111–135.
37.
WeijermanJ.E., HeybroecG.. Perforation in a case of submucous cleft palate due to aphthous ulcer.Br J Oral Maxillofac Surg.1972; 10: 217–219.
38.
YamamotoT., CuiX., ShulerC.F.. Role of ERK 1/2 signaling during EGF-induced inhibition of palatal fusion.Dev Biol.2003; 260: 512–521.
39.
ZhangZ., SongY., ZhaoX., ZhangX., FerminC., ChenY.. Rescue of cleft palate in Msx-1-deficient mice by transgenic Bmp4 reveals a network of BMP and Shh signaling in the regulation of mammalian palatogenesis.Development.2002; 129: 4135–4146.