Objective: Four head-related transfer function (HRTF) data sets were compared to determine the effect of HRTF measurement methodology on the localization of spatialized auditory stimuli. Background: Spatial audio interfaces typically require HRTF data sets to generate the spatialized auditory stimuli. HRTF measurement is accomplished using a variety of techniques that can require several nearly arbitrary decisions about methodology. The effects of these choices upon the resulting spatial audio interface are unclear. Method: Sixteen participants completed a sound localization task that included real-world, broadband stimuli spatialized at eight locations on the horizontal plane. Four different HRTF data sets were utilized to spatialize the stimuli: two publicly available HRTF data sets and two data sets obtained using different in-house measurement systems. All HRTFs were obtained from the Knowles Electronics Mannequin for Acoustics Research. Results: Unsigned localization error and proportion of front/back reversals did not differ significantly across HRTF data sets. Poorest accuracy was observed in locations near the medial (front/back) axis of the listener, mainly because of the relatively large proportions of reversals at these locations. Conclusion: This study suggests that the particular generalized HRTF data set chosen for spatialization is of minimal importance to the localizability of the resulting stimuli. Application: This result will inform the design of many spatial audio interfaces that are based upon generalized HRTFs, including wayfaring devices, communication systems, and virtual reality systems.