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Abstract

Paclitaxel, a diterpene natural product from the Pacific Yew tree, Taxus brevifolia, has emerged as a promising chemotherapeutic agent for treating solid tumors. We report here on the electronic absorbance and fluorescence spectra, fluorescence quantum yield, and excited-state fluorescence intensity decay kinetics of paclitaxel dissolved in several nonelectrolyte solvents. The results of these experiments show that the paclitaxel absorbance spectra are a function of paclitaxel concentration, consistent with concentration-dependent paclitaxel association. The paclitaxel molar absorptivity, fluorescence quantum yield, and radiative and nonradiative decay rates are all consistent with the excited state being of an (n, π*) type. We propose that this observation arises from one or both of the phenyl–C = O moieties in paclitaxel. To the best of our knowledge, this paper represents the first comprehensive report on the intrinsic fluorescence from any member of the taxane family.

Keywords

Paclitaxel Fluorescence Excited-state intensity decay kinetics Quantum yields Radiative and nonradiative rates Solvent effects

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On the Weak Intrinsic Luminescence from Paclitaxel Dissolved in Nonelectrolyte Solvents

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