Abstract
The surface-enhanced Raman scattering (SERS) spectra of model sebaceous gland secretions and their bacterially generated fatty acids are described. Long-chain fatty acids, their parent triglycerides, and long-chain hydrocarbons have characteristic SERS signatures that make them readily resolvable in heterogeneous mixtures. Silicon-substrate silver microprobes are shown to be useful for studying the spatial distribution of lipids and their corresponding fatty acids in nanoflow rate systems.
Keywords
Get full access to this article
View all access options for this article.
References
1.
Stewart
M. E.
Downing
D. T.
, Adv. Lipid Res. 24 , 263 (1991 ).
2.
Todd
E. A.
Morris
M. D.
, Appl. Spectrosc. 47 , 855 (1993 ).
3.
Zhelyaskov
V. R.
Milne
E. T.
Hetke
J. F.
Morris
M. D.
, Appl. Spectrosc. 49 , 1793 (1995 ).
4.
Siirila
A. R.
Bohn
P. W.
, Langmuir 7 , 2188 (1991 ).
5.
Page
J. A.
, “Electrogravimetry” , in Handbook of Analytical Chemistry ,
Meites
L.
, Ed. (McGraw Hill , New York , 1963 ), p. 171 .
6.
Najafi
K.
Wise
K. D.
, IEEE Trans. Biomed. Eng. 17 , 238 (1985 ).
7.
Anderson
D. J.
Najafi
K.
Tanghe
S. J.
Evans
D. A.
Levy
K. L.
Hetke
J. F.
Xue
X.
Zappia
J. J.
Wise
K. D.
, IEEE Trans. Biomed. Eng. 36 , 673 (1989 ).
8.
Todd
E. A.
Morris
M. D.
, Appl. Spectrosc. 48 , 545 (1994 ).
9.
Bewsher
A.
Powell
I.
Boland
W.
, Appl. Opt. 35 , 1654 (1996 ).
10.
Gaber
B. P.
Peticolas
W. L.
, Biochim. Biophys. Acta 465 , 260 (1977 ).
11.
Bryant
M. A.
Pemberton
J. E.
, J. Am. Chem. Soc. 113 , 8284 (1991 ).
12.
DuBois
L. H.
Zegarski
B. R.
Nuzzo
R. G.
, Langmuir , 2 , 412 (1986 ).
13.
Drumm
C. A.
Morris
M. D.
, Appl. Spectrosc. 49 , 1331 (1995 ).
14.
Hayden
C. A.
Morris
M. D.
, Appl. Spectrosc. 50 , 708 (1996 ).
15.
Jestel
N. L.
Shaver
J. M.
Morris
M. D.
, Appl. Spectrosc. 52 , 64 (1998 ).
16.
Aust
J. F.
Booksh
K. S.
Myrick
M. L.
, Appl. Spectrosc. 50 , 382 (1996 ).