Abstract
Fluorescence studies of hematoporphyrin derivative (HPD) in normal and tumor tissue of rat were performed with nitrogen laser excitation and optical multi-channel detection. Fifteen types of tissue including inoculated tumor were investigated for rats at different delays after HPD injection. Optimum contrast functions and other criteria for discriminating tumor tissue from normal tissue are discussed. The results should have implications for practical human HPD endoscopy.
Get full access to this article
View all access options for this article.
References
1.
Dougherty
T. J.
, CRC Critical Reviews in Oncology/Hematology ,
Davis
S.
Ed. (CRC Press , Florida , 1984 ).
2.Proc. of the Symposium on Porphyrin Localization and Treatment of Tumors ,
Doiron
D. R.
, Ed., Santa Barbara, California , April 24–28, 1983 .
3.Proc. of the International Symposium on Porphyrins in Tumor Phototherapy ,
Cubeddu
R.
, Ed., Milano, Italy , May 26–28, 1983 .
4.
Svanberg
K.
Svanberg
S.
, Lund Reports on Atomic Physics LRAP-23 (1983 ).
5.
Dougherty
T. J.
Kaufman
J. E.
Goldfarb
J. E.
Weishaupt
K. R.
Boyle
D.
Mittleman
A.
, Cancer Res. 38 , 2628 (1978 ).
6.
Wile
A. G.
Dahlman
A.
Burns
R. G.
Berns
M. W.
, Lasers in Surg, and Med. 2 , 163 (1982 ).
7.
Forbes
I. J.
Cowled
P. A.
Leong
A. S.-Y.
Ward
A. D.
Black
R. B.
Blake
A. J.
Jacka
F. J.
, Med. J. Aust. 2 , 489 (1980 ).
8.
Hayata
Y.
Kato
H.
Konaka
C.
Ono
J.
Tahizawa
T.
, Chest 81 , 269 (1982 ).
9.
Cortese
D.
Kinsey
J. H.
, Mayo Clin. Proc. 57 , 543 (1982 ).
10.
Kinsey
J. H.
Cortese
D. A.
Sanderson
D. R.
, Mayo Clin. Proc. 53 , 594 (1978 ).
11.
King
E. G.
Man
G.
le Riche
J.
Amy
R.
Profio
A. E.
Doiron
D. R.
, Cancer 49 , 777 (1982 ).
12.
Tsuchiya
A.
Obara
N.
Miwa
M.
Ohi
T.
Kato
H.
Hayata
Y.
, J. Urol. 130 , 79 (1983 ).
13.
Kinsey
J. H.
Cortese
D. A.
, Rev. Sci. Instr. 51 , 1403 (1980 ).
14.
Doiron
D. R.
Profio
E.
Vincent
R. G.
Dougherty
T. J.
, Chest 76 , 27 (1979 ).
15.
Celander
L.
Fredriksson
K.
Galle
B.
Svanberg
S.
, Göteborg Institute of Physics Reports GIPR-149 (1978 ).
16.
Herder
P.
Olsson
T.
Sjöblom
E.
Svanberg
S.
, Lund Reports on Atomic Physics LRAP-9 (1981 ).
17.
Montán
S.
, Lund Reports on Atomic Physics LRAP-17 (1982 ).
18.
Montán
S.
Svanberg
K.
Svanberg
S.
, unpublished results .
19.
Hedlund
G.
Sjögren
H. O.
, Int. J. Cancer 26 , 71 (1980 ).
20.
Montán
S.
, unpublished results .
21.
Berns
M. W.
Dahlman
A.
Johnson
F. M.
Burns
R.
Sperling
D.
Guiltinan
M.
Siemens
A.
Walter
R.
Wright
W.
Hammer-Wilson
M.
Wile
A.
, Cancer Res. 42 , 2325 (1982 ).
22.
Gomer
C. J.
Dougherty
T. J.
, Cancer Res. 39 , 146 (1979 ).
23.
Gomer
C. J.
Rucker
N.
Mark
C.
Benedict
W. F.
Murphee
A. L.
, Invest. Ophthalmol. Vis. Sci. 22 , 118 (1982 ).
24.
Montán
S.
Svanberg
S.
, unpublished results .
