Rhodamine 6G (R6G) doped thin films composed of poly(L-lactic acid) (PLLA) and Pluronic P104 were spin cast onto glass microscope slides and characterized by ultraviolet–visible, steady-state, and time-resolved fluorescence spectroscopy. The results show that R6G aggregation within the film increases as the R6G concentration and P104 loading increases. These results suggest an approach for studying drug distributions (monomers, aggregates) within biodegradable polymer formulations.
FuK.PackD. W.KilbanovA. M. and LangerR, Pharm. Res.17, 100 (2000).
5.
LuL. and MikosA. G, “Poly(lactic acid)”, in Polymer Data Handbook, MarkJ. E. Ed. (Oxford University Press, New York, 1999), p. 627.
6.
LuL.YaszemskiM. J. and MikosA. G, Biomaterials22, 3345 (2001).
7.
Shum-TimD.StockU.HrkachJ.ShinokaT.LienJ.MosesM. A.StampA.TaylorG.MoranA. M.LandisW.LangerR.VacantiJ. P. and MayerJ. E, Ann. Thor. Surg.68, 2298 (1999).
8.
ChoE. J.TaoZ.TangY.TehanE. C.BrightF. V.HicksW. L.Jr.GardellaJ. A.Jr., and HardR., J. Biomed. Mater. Res. A66, 417 (2003).
9.
LeeJ.GardellaJ. A.Jr.HicksW. H.Jr.HardR. and BrightF. V, Pharm. Res.20, 149 (2003).
10.
ParkJ. H.YeM. and ParkK, Molecules10, 146 (2005).
11.
TarvainenT.KarjalainenT.MalinM.PohjolainenS.TuominenJ.SeppalaJ. and JarvinenK, J. Control. Rel.81, 251 (2002).
12.
HedbergE. L.TangA.CrowtherR. S.CarneyD. H. and MikosA. G, J. Control. Rel.84, 137 (2002).
13.
HarvieF., “Poly-L-lactic Acid (PLA) in Surgery”, in Smith & Nephew Technical Brief (2000).
14.
DrumrightR. E.GruberP. R. and HentonD. E, Adv. Mater.12, 1841 (2000).
15.
ChoJ.BaratianS.KimJ.YehF.HsiaoB. S. and RuntJ, Polymer44, 711 (2003).
16.
Di LorenzoM. L., Macromol. Symp.234, 176 (2006).
17.
LiJ.HeY. and InoueY, Polymer Intern.52, 949 (2003).
18.
ParkT. G.CohenS. and LangerR, Macromolecules25, 116 (1992).
19.
UhrichK. E.CannizzaroS. M.LangerR. S. and ShakesheffK. M, Chem. Rev.99, 3181 (1999).
20.
NarangU.WangR.PrasadP. N. and BrightF. V, J. Phys. Chem.98, 17 (1994).
21.
WangJ.-H.BartlettJ. D.DunnA. C.SmallS.WillisS. L.DriverM. J. and LewisA. L, J. Microsc.217, 216 (2005).
22.
NarangU.BrightF. V. and PrasadP. N, Appl. Spectrosc.47, 229 (1993).
23.
VogelR.HarveyM.EdwardsG.MeredithP.HeckenbergN.TrauM. and Rubinsztein-DunlopH, Macromolecules35, 2063 (2002).
24.
YangP.WirnsbergerG.HuangH. C.CorderoS. R.McGeheeM. D.ScottB.DengT.WhitesidesG. M.ChmelkaB. F.BurattoS. K. and StuckyG. D, Science (Washington, D.C.)287, 465 (2000).
25.
BarrancoA. and GroeningP, Langmuir22, 6719 (2006).
26.
LitwilerK. S.KluczynskiP. M. and BrightF. V, Anal. Chem.63, 797 (1991).
27.
LiY.DingL. J.GongK. Y. and NakashimaK, J. Photochem. Photobiol. A: Chem.161, 125 (2004).
28.
Del MonteF.MackenzieJ. D. and LevyD, Langmuir16, 7377 (2000).
29.
BojarskiP., Chem. Phys. Lett.278, 225 (1997).
30.
GabrilenkoV. I. and NoginovM. A, J. Chem. Phys.124, 44301 (2006).
31.
VogelR.MeredithP.HarveyM. D. and sztein-DunlopRubin H, Spectrochim. Acta, Part A60, 245 (2004).
32.
BerklandC.PollaufE.RamanC.SilvermanR.KimK. and PackD. W, J. Pharm. Sci.96, 1176 (2006).
33.
LeeS.KimM. S.KimJ. S.ParkH. J.WooJ. S.LeeB. C. and HwangS. J, J. Microencap.23, 741 (2006).
34.
PanC. J.TangJ. J.WengY. J.WangJ. and HuangN, J. Cont. Release116, 42 (2006).
35.
NairL. S. and LaurencinC. T, Adv. Biochem. Eng. Biotechnol.102, 47 (2006).
