Optical sensing of glucose would allow more frequent monitoring and tighter glucose control for people with diabetes. The key to a successful optical noninvasive measurement of glucose is the collection of an optical spectrum with a very high signal-to-noise ratio in a spectral region with significant glucose absorption. Unfortunately, the optical throughput of skin is low due to absorption and scattering. To overcome these difficulties, we have developed a high-brightness tunable laser system for measurements in the 2.0–2.5 μm wavelength range. The system is based on a 2.3 μm wavelength, strained quantum-well laser diode incorporating GaInAsSb wells and AlGaAsSb barrier and cladding layers. Wavelength control is provided by coupling the laser diode to an external cavity that includes an acousto-optic tunable filter. Tuning ranges of greater than 110 nm have been obtained. Because the tunable filter has no moving parts, scans can be completed very quickly, typically in less than 10 ms. We describe the performance of the present laser system and avenues for extending the tuning range beyond 400 nm.
Diabetes Control and Complications Trial Research Group, “The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus”, N. Engl. J. Med.329, 977 (1993).
2.
Diabetes in America, NIH Publication No. 95–1468 (National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 1995), 2nd ed.
3.
RayN. F.ThamerM.GardnerE.ChanJ. K. and KahnR, Diabetes Care21, 296 (1998).
4.
KhalilO. S., Clin. Chem.45, 165 (1999).
5.
OlesbergJ. T.LiuL.Van ZeeV. and ArnoldM. A, Proc. SPIE-Int. Soc. Opt. Eng.5325, 11 (2004).
6.
WangJ.MaiorovM.JeffriesJ. B.GarbuzovD. Z.ConnollyJ. C. and HansonR. K, Meas. Sci. Technol.11, 1576 (2000).
7.
WangJ.MaiorovM.BaerD. S.GarbuzovD. Z.ConnollyJ. C. and HansonR. K, Appl. Opt.39, 5579 (2000).
8.
NicolasJ. C.BaranovA. N.CuminalY.RouillardY. and AlibertC, Appl. Opt.37, 7906 (1998).
9.
XuL. H.LiuZ. F.YakovlevI.TretyakovM. Y. and LeesR. M, Infrared Phys. Technol.45, 31 (2004).
10.
MayR. D., J. Geophys. Res.103, 19161 (1998).
11.
BrookesM. D. and McKellarA. R. W, J. Chem. Phys.109, 5823 (1998).
12.
WebsterC. R.FleschG. J.ScottD. C.SwansonJ. E.MayR. D.WoodwardW. S.GmachlC.CapassoF.SivcoD. L.BaillargeonJ. N.HutchinsonA. L. and ChoA. Y, Appl. Opt.40, 321 (2001).
13.
NamjouK.CaiS.WhittakerE. A.FaistJ.GmachlC.CapassoF.SivcoD. L. and ChoA. Y, Opt. Lett.23, 219 (1998).
14.
AdamiecP.SalhiA.BohdanR.BerchaA.DybalaF.TrzeciakowskiW.RouillardY. and JoullieA, Appl. Phys. Lett.85, 4292 (2004).
15.
AdamiecP.DybalaF.BerchaA.BohdanR.TrzeciakowskiW. and OsinskiM, Proc. SPIE-Int. Soc. Opt. Eng.4973, 158 (2003).
16.
DybalaF.AdamiecP.BerchaA.BohdanR. and TrzeciakowskiW, Proc. SPIE-Int. Soc. Opt. Eng.4989, 181 (2003).
17.
BagleyM.WyattR.EltonD. J.WickesH. J.SpurdensP. C.SeltzerC. P.CooperD. M. and DevlinW. J, Electron. Lett.26, 267 (1990).
18.
TabuchiH. and IshikawaH, Electron. Lett.26, 742 (1990).
19.
LeH. Q.TurnerG. W.OchoaJ. R.ManfraM. J.CookC. C. and ZhangY.-H, Appl. Phys. Lett.69, 2804 (1996).
20.
LeH. Q.TurnerG. W.OchoaJ. R.ManfraM. J.CookC. C. and ZhangY.-H, Proc. SPIE-Int. Soc. Opt. Eng.3001, 298 (1997).
21.
MermelsteinC.SimanowskiS.MayerM.KieferR.SchmitzJ.WaltherM. and WagnerJ, Appl. Phys. Lett.77, 1581 (2000).
22.
SimanowskiS.HerresN.MermelsteinC.KieferR.SchmitzJ.WaltherM.WagnerJ. and WeimannG, J. Cryst. Growth209, 15 (2000).
23.
SimanowskiS.MermelsteinC.WaltherM.HerresN.KieferR.RattundeM.SchmitzJ.WagnerJ. and WeimannG, J. Cryst. Growth227, 595 (2001).
24.
SimanowskiS.WaltherM.SchmitzJ.KieferR.HerresN.FuchsF.MaierM.MermelsteinC.WagnerJ. and WeimannG, J. Cryst. Growth202, 849 (1999).
25.
MehuysD.WelchD. and ScifresD, Electron. Lett.29, 1254 (1993).
26.
AhmedM. and YamadaM, J. Appl. Phys.95, 7573 (2004).
27.
AbdulrhmannS. G.AhmedM.OkamotoT.IshimoriW. and YamadaM, IEEE J. Sel. Top. Quant. Electron.9, 1265 (2003).
28.
PetermannK., IEEE J. Sel. Top. Quant. Electron.1, 480 (1995).
29.
GreinC. H.FlattéM. E.OlesbergJ. T.AnsonS. A.ZhangL. and BoggessT. F, J. Appl. Phys.92, 7311 (2002).
30.
LauW. H.OlesbergJ. T. and FlattéM. E, Phys. Rev. B64, 161301 (2001).
31.
OlesbergJ. T.LauW. H.FlattéM. E.YuC.AltunkayaE.ShawE. M.HasenbergT. C. and BoggessT. F, Phys. Rev. B64, 201301 (2001).
32.
AnsonS. A.OlesbergJ. T.FlattéM. E.HasenbergT. C. and BoggessT. F, J. Appl. Phys.86, 713 (1999).
33.
FlattéM. E.GreinC. H.HasenbergT. C.AnsonS. A.JangD.-J.OlesbergJ. T. and BoggessT. F, Phys. Rev. B59, 5745 (1999).
34.
JangD.-J.FlattéM. E.GreinC. H.OlesbergJ. T.HasenbergT. C. and BoggessT. F, Phys. Rev. B58, 13047 (1998).
35.
OlesbergJ. T.AnsonS. A.McCahonS. W.FlattéM. E.BoggessT. F.ChowD. H. and HasenbergT. C, Appl. Phys. Lett.72, 229 (1998).
36.
RattundeM.HuelsmannA.SchmitzJ.KaufelG.WeberJ.MikullaM. and WagnerJ, Proc. SPIE-Int. Soc. Opt. Eng., paper in press (2005).
37.
WagnerJ., Proc. SPIE-Int. Soc. Opt. Eng., paper in press (2005).
38.
SwansonT., Photon. Spectra36, 78 (2002).
39.
LealmanI. F.KellyA. E.RiversL. J.PerrinS. D. and MooreR, Electron. Lett.34, 2247 (1998).
40.
MasonB.BartonJ.FishG. A.ColdrenL. A. and DenBaarsS. P, IEEE Photon. Technol. Lett.12, 762 (2000).
41.
WilliamsonC. A.AdamsM. J.EllisA. D. and BorghesaniA, Appl. Phys. Lett.82, 322 (2003).
42.
LinC.-F.SuY.-S. and WuB.-R, IEEE Photon. Technol. Lett.14, 3 (2002).
