Abstract
Epigenetics is defined as the study of mitotically and/or meiotically heritable traits that are not due to a change in DNA sequence. In mammalian cells, the most widely studied epigenetic events are DNA cytosine methylation, histone modifications, and chromatin remodeling. These processes are involved in a wide range of normal biological functions, including X chromosome inactivation, genomic imprinting, and tissue-specific gene expression. However, abnormalities in any of these systems can contribute to tumorigenesis, psychiatric disorders, and defects in somatic cell cloning, to name a few.
This first edition authoritative text, Epigenetics, is a remarkable compilation of 24 chapters written by world-renowned leaders in their fields. Targeted for advanced undergraduate, graduate, and professional students, the book covers the history of the field to cutting edge research of today, including major research challenges that need to be addressed. Each chapter begins with a general summary, and throughout the book the chapters are well written and well referenced. Chapters cover model organisms, such as yeast, worms, flies, and plants, as well as mammals. The conceptual basis for each chapter is clearly explained and bolstered by abundant, high-quality color figures. Information is up to date and provides the reader with a solid background on molecular mechanisms and biological relevance. Of the 2 appendices, 1 provides information on over 50 websites related to epigenetics, and another lists individual histone modifications in various models, their function, and references to primary literature. This book will be very useful to both beginners and those more experienced in epigenetic research and will undoubtedly become a “must have” for years to come.