Abstract
This handy toxicology reference provides practical and concise guidance for individuals involved in generating toxicology data, evaluating results from toxicology studies, and performing risk assessments of new pharmaceutical, biotechnical, and chemical products and materials. Although written primarily for toxicologists, this text would also be useful for industry pathologists who play key roles in some or all of these activities; however, the information is unlikely to be of interest to veterinary pathologists in general. As in the original edition, chapters focus on different areas of toxicity testing such as Good Laboratory Practices, animal and in-vitro test systems, metabolism and toxicokinetics, pathology, acute toxicology, multidose general toxicology, genetic toxicology, carcinogenicity studies, juvenile animal toxicology, developmental and reproductive toxicology, neurotoxicology testing, immune system toxicological assessment, inhalation and pulmonary toxicity, and cancer risk assessment. New chapters regarding safety pharmacology, juvenile studies, pharmaceutical health safety assessment, and food and cosmetic health assessment strategies have been added in this second addition to reflect more-recent changes to regulatory requirements. The text benefits from having numerous regulatory agency contributors to ensure that each chapter properly discusses the various regulatory requirements to facilitate compliance and approval. A comprehensive and up to date reference list follows each chapter allowing for further investigation of a topic if desired. Overall, this text succeeds in maintaining a non-biased and well-rounded discussion on the diverse components and proper conductance of toxicology studies. The book's layout is practical, and if a certain topic is desired, an in-depth index quickly provides quick and easy access to the desired information. Hayes's 1900+ page “Principles and Methods of Toxicology” may serve as a more complete and core reference regarding toxicology testing procedures; however, Jacobsen-Kram's 500-page handbook is a more concise and useable toxicology methods reference for industry pathologists.