Consider a Patient's Weight and the Weight of the Evidence When Calculating Renal Function

Product information. Tikosyn (dofetilide). New York, NY: Pfizer, February 2011.

Product information. Integrelin (eptifibatide). Whitehouse Station, NJ: Merck and Co., July 2012.

Lexi-Comp Inc. Hudson, OH: Lexi-Comp, expires December 31, 2013 (accessed 2013 Mar 11).

Park EJ , Pai M , Dong T , et al. The influence of body size descriptors on the estimation of kidney function in normal weight, overweight, obese, and morbidly obese adults. Ann Pharmacother 2012; 46: 317–28. DOI: 10.1345/aph.1Q374

Demirovic JA , Pai AB , Pai M. Estimation of creatinine clearance in morbidly obese patients. Am J Health Syst Pharm 2009; 66: 642–8. DOI: 102146/ajhp080200

Pedersen OD , Bagger H , Keller N , et al. Efficacy of dofetilide in the treatment of atrial fibrillation-flutter in patients with reduced left ventricular function: a Danish investigation of arrhythmia and mortality on dofetilide (DIAMOND) substudy. Circulation 2001; 104: 292–6. DOI: 10.1161/01CIR.104.3.292

The EINSTEIN Investigators. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med 2010; 363: 2499–510. DOI: 10.1056/NEJMoa1007903

Patel MR , Mahaffey KW , Garg J , et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med 2011; 365: 883–91. DOI: 10.1056/NEJMoa1009638