High- versus Low-Dose Oxytocin for Augmentation or Induction of Labor

Abstract

OBJECTIVE:

To compare the use of high- and low-dose oxytocin for augmentation or induction of labor.

DATA SOURCES:

Clinical trials were accessed through MEDLINE (1966–November 2003). Published literature relevant to the use of oxytocin for augmentation or induction of labor was evaluated.

STUDY SELECTION AND DATA EXTRACTION:

Articles identified from the data sources were evaluated and included if they were clinical trials comparing high- versus low-dose oxytocin for augmentation or induction of labor.

DATA SYNTHESIS:

Oxytocin is a treatment of choice for augmentation and induction of labor; however, no consensus exists regarding optimal dosing. Relevant studies comparing high-dose (2–6 mU/min) and low-dose (1–2 mU/min) therapy for labor augmentation and induction were evaluated.

CONCLUSIONS:

High-dose oxytocin decreases the time from admission to vaginal delivery, but does not appear to decrease the incidence of cesarean sections when compared with low-dose therapy.