To review the literature evaluating the use of selective serotonin-reuptake inhibitors (SSRIs) for the treatment of hot flashes.
DATA SOURCES:
Biomedical literature was accessed through MEDLINE (1966—June 2003), MD Consult, and references of reviewed articles. Key search terms used were hot flashes, vasomotor symptoms, antidepressants, and SSRIs.
DATA SYNTHESIS:
Recent evidence from the Women's Health Initiative precludes the use of traditional hormonal therapy in some women. Nonhormonal therapies are possible options, but conflicting evidence of efficacy exists.
CONCLUSIONS:
Although further studies are warranted, preliminary data suggest that SSRIs are generally modestly successful in reducing the frequency and severity of hot flashes.
Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA2002;288:321–33.
KronenbergF.Hot flashes: Phenomenology, quality of life, and search for treatment options. Exp Gerontol1994;29:319–36.
4.
KronenbergF.Hot flashes: Epidemiology and physiology. Ann NY Acad Sci1990;592:52–86.
5.
WeitznerMAMoncelleJJacobsenPBMintonS.A pilot trial of paroxetine for the treatment of hot flashes and associated symptoms in women with breast cancer. J Pain Symptom Manage2002;23:337–45.
6.
BerendsenH.The role of serotonin in hot flushes. Maturitas2000;36;155–64.
7.
StearnsVIsaacsCRowlandJCrawfordJEllisMJKramerRA pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil) in controlling hot flashes in breast cancer survivors. Ann Oncol2000;11: 17–22.
8.
StearnsVBeebeKLIyengarMDubeE.Paroxetine controlled release in the treatment of menopausal hot flashes. JAMA2003;289:2827–34.
9.
LoprinziCSloanJPerezEQuellaSStellaPJMailliardJAPhase III evaluation of fluoxetine for treatment of hot flashes. J Clin Oncol2002;20:1578–83.
10.
KimmickGGLovatoJMcQuellonRRobinsonEMussH.Randomized, placebo-controlled study of sertraline (Zoloft) for the treatment of hot flashes in women with early stage breast cancer taking tamoxifen (abstract no. 1585). Presented at the American Society of Clinical Oncology Annual Meeting, San Francisco, CA, May 12–15, 2001. www.asco.org (accessed 2004 Mar 8).
