Effect of Cyclooxygenase-2 Inhibitors on Blood Pressure

Abstract

OBJECTIVE:

To evaluate the effect of cyclooxygenase-2 selective inhibitors (CSIs) on blood pressure.

DATA SOURCES:

Clinical literature accessed through MEDLINE (1966–May 2002). Key search terms included COX-2 selective inhibitors; anti-inflammatory agents, nonsteroidal; celecoxib; rofecoxib; and hypertension.

DATA SYNTHESIS:

Data from prospective studies on the effects of CSIs on blood pressure are conflicting. Several studies have reported increased blood pressure as an adverse effect of CSIs.

CONCLUSIONS:

Additional studies are needed to evaluate the effects of CSIs on blood pressure. CSIs should be used with caution in hypertensive patients and blood pressure monitored closely if a CSI is indicated.