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Abstract

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French

OBJECTIVE:

To evaluate the role of budesonide inhalation suspension (BIS) in the treatment of children with asthma.

DATA SOURCES:

Literature identified through Medline (1966–November 2000) and references obtained from selected articles. Search terms included budesonide and asthma.

DATA SYNTHESIS:

Asthma is a chronic inflammatory disease that affects approximately 4.8 million children in the US. By reducing inflammation, corticosteroids decrease symptoms and improve lung function. As the first nebulized corticosteroid, BIS offers an important treatment option for children with persistent asthma.

CONCLUSIONS:

BIS is effective in reducing symptoms and improving lung function in children with asthma. It should be used in children ages 1–8 years with moderate to severe persistent asthma who are unable to effectively use a metered-dose inhaler with or without a spacer or a dry-powder inhaler.

Keywords

asthma budesonide children

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References

National Asthma Education and Prevention Program. Expert panel report 2. Guidelines for the diagnosis and management of asthma. Bethesda, MD: National Institutes of Health—National Heart, Lung, and Blood Institute, 1997: 1–86.

National Asthma Education and Prevention Program. Practical guide for the diagnosis and management of asthma. Bethesda, MD: Dept. of Health and Human Services, Public Health Service, National Institutes of Health, NIH Publication 97–4053.

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Pedersen

. Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 1994; 88: 373–81.

Mellon

. Efficacy of budesonide inhalation suspension in infants and young children with persistent asthma. J Allergy Clin Immunol 1999; 104 (Suppl):S191–9.

Baker

Mellon

Wald

Welch

Cruz-Rivera

Walton-Bowen

. A multiple-dosing, placebo-controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants. Pediatrics 1999; 103: 414–20.

Shapiro

Mendelson

Kraemer

Cruz-Rivera

Walton-Bowen

Smith

. Efficacy and safety of budesonide inhalation suspension (Pulmicort Respules) in young children with inhaled steroid-dependent, persistent asthma. J Allergy Clin Immunol 1998; 102: 789–96.

Kemp

Skoner

Szefler

Walton-Bowen

Cruz-Rivera

Smith

. Once-daily budesonide inhalation suspension for the treatment of persistent asthma in infants and young children. Ann Allergy Asthma Immunol 1999; 83: 231–9.

Campbell

. Once-daily inhaled corticosteroids in mild to moderate asthma: Improving acceptance of treatment. Drugs 1999; 58: 25–33.

Shapiro

. Once-daily inhaled corticosteroids in children with asthma: Nebulisation. Drugs 1999; 58: 43–9.

10.

Mellon

Leflein

Walton-Bowen

Cruz-Rivera

Fitzpatrick

Smith

. Comparable efficacy of administration with face mask or mouthpiece of nebulized budesonide inhalation suspension for infants and young children with persistent asthma. Am J Respir Crit Care Med 2000; 162: 593–8.

11.

Package insert. Pulmicort Respules (budesonide inhalation suspension). Wayne, PA; AstraZeneca, August 2000.

12.

Scott

Skoner

. Short-term and long-term safety of budesonide in infants and young children with persistent asthma. J Allergy Clin Immunol 1999; 104 (Suppl):S200–9.

13.

Skoner

Stanley

Welch

Walton-Bowen

Cruz-Rivera

Smith

. Longitudinal growth in infants and young children treated with budesonide inhalation suspension for persistent asthma. J Allergy Clin Immunol 2000; 105: 259–68.

14.

Szefler

. Pharmacodynamics and pharmacokinetics of budesonide: A new nebulized corticosteroid. J Allergy Clin Immunol 1999; 104 (Suppl):S175–82.

15.

Agertoft

Pedersen

. Effect of long-term treatment with inhaled budesonide on adult height in children with asthma. N Engl J Med 2000; 343: 1064–9.

16.

Bisgaard

Nikander

Munch

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Role of Budesonide Inhalation Suspension in Children with Asthma

Abstract

OBJECTIVE:

DATA SOURCES:

DATA SYNTHESIS:

CONCLUSIONS:

Keywords

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References