Management Protocol for Abacavir-Related Hypersensitivity Reaction

Abstract

OBJECTIVE:

To develop an abacavir hypersensitivity reaction management protocol for the University of Oklahoma Health Sciences Center.

DATA SYNTHESIS:

Conference abstracts, published literature, and manufacturer-provided materials were reviewed to define the syndrome and manifestations and to recommend steps to take when a patient develops abacavir-related reactions.

RESULTS:

Initial education, formalized contact and response mechanism, and intervention levels were incorporated into a protocol for clinicians.

CONCLUSIONS:

Abacavir, a newly approved agent for the treatment of HIV, has been associated with a fatal hypersensitivity reaction. Our protocol provides a mechanism to minimize progression of abacavir hypersensitivity reaction by providing a formalized management procedure