Colchicine is one of the oldest medications still in use today and is commonly used for the treatment of gout and familial Mediterranean fever. Its anti-inflammatory properties have raised the question of its utility in managing several cardiovascular diseases, including postoperative atrial fibrillation and pericarditis. This article will review the evidence for colchicine in these conditions and provide recommendations for use.
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References
1.
KesselheimAS, SolomonDH. Incentives for drug development – the curious case of colchicine. N Engl J Med.2010;362:2045–2047.
2.
DeftereosS, GiannopouloG, PapoutsidakisN, Colchicine and the heart. J Am Coll Cardiol.2013;62:1817–1825.
3.
EchahidiN, PibarotP, O'HaraG, Mechanisms, prevention, and treatment of atrial fibrillation after cardiac surgery. J Am Coll Cardiol.2008:51:793–801.
4.
ImazioM, BrucatoA, FerrazziP, Colchicine reduces postoperative atrial fibrillation: Results of the Colchicine for the Prevention of the Postpericardiotomy Syndrome (COPPS) atrial fibrillation substudy. Circulation. 2011;124:2290–2295.
5.
DavisEM, PackardKA, HillemanDE. Pharmacologic prophylaxis of postoperative atrial fibrillation in patients undergoing cardiac surgery: Beyond β-blockers. Pharmacotherapy. 2010;30:274e–318e.
6.
MatthewJP, FontesML, TudorIC, A multicenter risk index for atrial fibrillation after cardiac surgery. JAMA. 2004;291:1720–1729.
7.
MackDR, CahoonWDJr., LoweDK. Colchicine for the primary prevention of the postpericardiotomy syndrome. Ann Pharmacother.2011;45:803–806.
8.
ImazioM, BrucatoA, FerrazziP, Colchicine for the prevention of the post-pericardiotomy syndrome (COPPS): A multicenter, randomized, double-blind, placebo-controlled trial. Eur Heart J.2010;31:2749–2754.
9.
BradleyD, CreswellLL, HogueCW, Pharmacologic prophylaxis: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery. CHEST. 2005;128:39S–47S.
10.
HillisLD, SmithPK, AndersonJL, 2011 ACCF/AHA Guideline for Coronary Artery Bypass Graft Surgery: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(23):e652–735.
11.
JanuaryCT, WannLS, AlbertJS, 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014;130(23):e199–267.
12.
ImazioMColchicine for the prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: The COPPS-2 randomized clinical trial. JAMA. 2014;312: 1016–1023.
13.
NorridSE, OliphantCS. Colchicine for the treatment of acute and recurrent pericarditis. Ann Pharmacother.2014;48:1050–1054.
14.
ImazioM, BobbioM, CecchiE, Colchicine in addition to conventional therapy for acute pericarditis: Results of the colchicine in acute pericarditis (COPE) trial. Circulation. 2005;112:2012–2016.
15.
ImazioM, BrucataA, CeminR, A randomized trial of colchicine for acute pericarditis (ICAP). N Engl J Med.2013;369:1522–1528.
16.
MaischB, SeferovicPM, RisticAD, Guidelines on the diagnosis and management of pericardial diseases executive summary; The Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Eur Heart J.2004;25:587–610.
17.
ImazioM, SpodickD, BrucatoA, Controversial issues in the management of pericardial diseases. Circulation. 2010;121:916–928.
ImazioM.Treatment of recurrent pericarditis. Rev Esp Cardiol.2014;67:345–348.
20.
MaischB, SeferovićPM, RistićAD, , and the Task Force on the Diagnosis and Management of Pericardial Diseases of the European Society of Cardiology. Guidelines on the diagnosis and management of pericardial diseases executive summary. Eur Heart J.2004;25:587–610.
21.
ImazioM, BobbioM, CecchiE, Colchicine as firstchoice therapy for recurrent pericarditis. Arch Intern Med.2005;165:1987–1991.
22.
ImazioM, BrucatoA, CeminR, Colchicine for recurrent pericarditis (CORP). Ann Intern Med.2011;155:409–414.
23.
ImazioM, BelliR, BrucatoA, Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): A multicentre, double-blind, placebo-controlled, randomized trial. Lancet. 2014;383:2232–2237.