Nutrition Support Pharmacist features issues pertinent to the practice of clinical pharmacy in the area of metabolic support. In this review, a critical analysis of six current major intensive insulin therapy trials (Leuven I, Leuven II, Leuven III, NICE-SUGAR, VISEP, and Glucontrol) for critically ill surgical and medical patients is provided. Practical suggestions for managing hyperglycemia, defining an effective target blood glucose concentration range, avoiding hypoglycemia, and designing a safe and effective insulin infusion algorithm are given.
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