High-Dose Insulin in the Treatment of Antihypertensive Overdose

Abstract

Objective

To describe a case of calcium channel blocker overdose along with an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker, which was successfully treated with high-dose insulin with dextrose and potassium supplementation (HDIDK).

Case Summary

A 52-year-old woman was transferred to an admitting hospital after ingesting 14 tablets of trandolapril/verapamil SR (Tarka)4 mg/240 mg, 15 to 16 tablets of olmesartan (Benicar) 20 mg, and an unknown amount of (escitalopram) Lexapro combined with unknown quantities of alcohol and benzodiazepines. This combination caused hypotension and electrocardiogram changes. The patient was treated for hypotension-induced shock with epinephrine, glucagon, HDIDK, magnesium, and fluids. An insulin infusion ran for 24 hours. The patient was discharged to a psychiatric facility 3 days after admission.

Discussion

The non-dihydropyridine, verapamil, causes dilation of the coronary and peripheral vasculature by inhibiting the influx of calcium ions through L-type calcium channels. HDIDK is thought to be a useful treatment in the state of hypoinsulinemia, which prevents the uptake of glucose by myocytes and can lead to decreased inotropy and eventually shock. High-dose insulin allows glucose to be properly used for energy by the myocytes.

Conclusions

Currently HDIDK therapy is recommended as an adjunct to conventional therapy in calcium channel blocker poisoning only after fluids, high-dose calcium salts, and vasopressors. In this case, early implementation of HDIDK treatment was shown to shorten the length of therapy.