A 23-year-old young adult, who had no previous illness, suffered from anterior wall acute myocardial infarction, right renal infarction and occlusion of the left distal brachial artery, popliteal artery, and tibioperoneal trunk artery within six months. He had a habit of smoking but denied a history of drug abuse. Protein C deficiency was diagnosed via the examination of a hypercoagulable panel. The investigation of the hypercoagulable state is essential in young adults with an unusual presentation of artery occlusion.
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