The cause of endomyocardial fibrosis in Uganda remains unknown in spite of studies dating back to 1948. Herbal decoctions have been used by traditional healers for countless generations to treat many complaints, especially fever. We present evidence – ethnic, geographical, tribal, pathological and distribution by age – that the toxic herbal decoctions taken as medicines in Uganda can cause endomyocardial fibrosis.
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References
1.
DaviesJNP. Endocardial fibrosis in Uganda.East African Med J1948; 25: 10
2.
DaviesJN. The ridge in endomyocardial fibrosis.Lancet1968; 1: 631–2.
3.
ConnorDH, SomersK, HuttMS, ManionWC, D'ArbelaPG. Endomyocardial fibrosis in Uganda (Davies’ disease). Part 1. An epidemiologic, clinical and pathologic study.Am Heart J1967; 74: 687
4.
ConnorDH, SomersK, HuttMS, ManionWC, D'ArbelaPG. Endomyocardial fibrosis in Uganda (Davies’ disease). Part 2. An epidemiologic, clinical and pathologic study.Am Heart J1968; 75: 107
5.
DasM, KhannaSK. Clinicoepidemiological, toxicological, and safety evaluation studies on Argemone oil.Crit Rev Toxicol1997; 27: 273–97.
6.
BrinkAJ, LewisCM, WeberHW. Myocardiopathy in Argemone mexicana poisoning.S Afr Med J1965; 39: 108–14.
7.
SharmaBD, MalhotraS, BhatiaV, RatheeM. Epidemic dropsy in India.Postgrad Med J1999; 75: 657–61.
8.
SoodNN, SachdevM.S, MohanM, GuptaSK, SachdevHP. Epidemic dropsy following transcutaneous absorption of Argemone mexicana oil.Trans R Soc Trop Med Hyg1985; 79: 510–12.
9.
WattJM, Breyer-BrandwijkMG. The Medicinal and Poisonous Plants of Southern and Eastern Africa.2nd edn.London: E & S Livingston, 1962: 901
10.
ConnorDH. African Cardiomyopathies. WHO Special Report. Geneva: World Health Organization, 1964
11.
GratzB. Argemone mexicana decoction versus artesunate-amodiaquine for the management of malaria in Mali: policy and public-health implications.Trans R Soc Trop Med Hyg2010; 104: 33–41.
12.
RahmanMS, SalehinMF, JamalMAHM, ParvinA, AlamMK. Antibacterial activity of Argemone mexicana L. against water borne microbes.Res J Med Plant2011; 5: 621–6.