The causative factors and ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis are reported here. Six out of seven patients developed the syndrome secondary to ingestion of sulphadoxine/pyrimethamine while one developed it as a complication of HAART (highly active antiretroviral therapy). The ocular complications were ankyloblepharon, symblepharon, chronic conjunctivitis, corneal vascularization and conjunctivalization, and blindness. One patient died. A shift to the WHO-recommened artemisin-based combination therapy for the treatment of malaria is advised. Early referral to the ophthalmologist will help to reduce the complications.
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References
1.
PowerWJ, GhoraishiM, MereyoL.Analysis of the acute ophthalmic manifestations of the erythema multiforme Stevens-Johnson syndrome/toxic epidermal necrolysis disease spectrum.Ophthalmology1995; 102: 1669–76.
ErhaborO, EjeleOA, UkoEK.HAART dependent CD4+ lymphocyte response based on pre therapeutic CD4 lymphocyte count in HIV infected Nigerians.Ann Afr Med2006; 5: 153–7.
4.
ArrtikaitisMJ.Ocular aftermath of Stevens-Johnson syndrome. Review of 33 cases.Arch Ophthalmol1973; 90: 376–9.
5.
OshikoyaKA.Malaria treatment in Lagos private clinics/hospitals: physicians compliance with the World Health Organisation recommendations.Nig Med Pract2006; 49: 102–10.
6.
KestelynP, LewallenS.Ocular problems with HIV infection and AIDS in Africa.J Comm Eye Health1995; 8: 19–23.
7.
KobayashiA, YoshitaT, SugiyamaK.Amniotic membrane transplantation on acute phase of toxic epidermal necrolysis with severe corneal involvement.Ophthalmology2006; 113: 126–32.
